BDBM50592094 CHEMBL5203605

SMILES OC(=O)c1cc(O)n(n1)-c1cccc(c1)C(F)(F)F

InChI Key InChIKey=VBTBURGKMCKOJC-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50592094   

TargetRNA demethylase ALKBH5(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM50592094(CHEMBL5203605)
Affinity DataIC50: 21nMAssay Description:Inhibition of human recombinant ALKBH5 (66 to 292 residues) expressed in Escherichia coli BL21 (DE3) cells using FAM-labeled ssRNA (5'-CUCGAUACG(m^6A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetNucleic acid dioxygenase ALKBH1(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM50592094(CHEMBL5203605)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of ALKHB1 (unknown origin) mediated demethylation of m6A assessed as enzyme substrate binding by fluorescence polarisation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM50592094(CHEMBL5203605)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of FTO (unknown origin) mediated demethylation of m6A assessed as disruption of enzyme substrate binding by fluorescence polarisation assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed