BDBM50591346 CHEMBL5188924::US20240190828, Compound 5

SMILES Fc1cccc(Cl)c1C1NC(=O)c2ccccc2N1

InChI Key InChIKey=DUZLGCVFNSELGL-UHFFFAOYSA-N

Data  1 IC50  8 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50591346   

TargetProtein polybromo-1(Human)
Medical College of Wisconsin

Curated by ChEMBL
LigandPNGBDBM50591346(CHEMBL5188924 | US20240190828, Compound 5)
Affinity DataKd:  1.84E+4nMAssay Description:Binding affinity to His-TEV-tagged recombinant human PBRM1 BD2 transfected in Escherichia coli BL21 (DE3) assessed as dissociation constant at 30 uM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetProtein polybromo-1(Human)
Medical College of Wisconsin

Curated by ChEMBL
LigandPNGBDBM50591346(CHEMBL5188924 | US20240190828, Compound 5)
Affinity DataKd:  1.79E+5nMAssay Description:Binding affinity to His-TEV-tagged human PBRM1 BD5 transfected in Escherichia coli BL21 (DE3) assessed as dissociation constant at 30 uM by ITC analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetProbable global transcription activator SNF2L2(Human)
Medical College of Wisconsin

Curated by ChEMBL
LigandPNGBDBM50591346(CHEMBL5188924 | US20240190828, Compound 5)
Affinity DataKd:  1.59E+4nMAssay Description:Binding affinity to N-terminal His6-TEV-tagged human SMARCA2B transfected in Escherichia coli BL21 (DE3) assessed as dissociation constant at 30 uM b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetTranscription activator BRG1(Human)
Medical College of Wisconsin

Curated by ChEMBL
LigandPNGBDBM50591346(CHEMBL5188924 | US20240190828, Compound 5)
Affinity DataKd:  1.42E+5nMAssay Description:Binding affinity to N-terminal His-TEV-tagged human SMARCA4 transfected in Escherichia coli BL21 (DE3) assessed as dissociation constant at 30 uM by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetProtein polybromo-1(Human)
Medical College of Wisconsin

Curated by ChEMBL
LigandPNGBDBM50591346(CHEMBL5188924 | US20240190828, Compound 5)
Affinity DataKd:  4.53E+4nMAssay Description:Binding affinity to 15N-labeled recombinant human PBRM1 BD2 transfected in Escherichia coli BL21 (DE3) assessed as 1H/13N chemical shift perturbation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetProtein polybromo-1 [200-270](Human)
The Medical College of Wisconsin, Inc.

US Patent
LigandPNGBDBM50591346(CHEMBL5188924 | US20240190828, Compound 5)
Affinity DataIC50: 4.20E+3nMAssay Description:No detail is given.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
Go to US Patent

TargetProtein polybromo-1 [200-270](Human)
The Medical College of Wisconsin, Inc.

US Patent
LigandPNGBDBM50591346(CHEMBL5188924 | US20240190828, Compound 5)
Affinity DataKd:  1.84E+4nMAssay Description:No detail is given.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
Go to US Patent

TargetProtein polybromo-1 [676-746](Human)
The Medical College of Wisconsin, Inc.

US Patent
LigandPNGBDBM50591346(CHEMBL5188924 | US20240190828, Compound 5)
Affinity DataKd:  1.79E+5nMAssay Description:No detail is given.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
Go to US Patent

TargetProtein polybromo-1 [200-270](Human)
The Medical College of Wisconsin, Inc.

US Patent
LigandPNGBDBM50591346(CHEMBL5188924 | US20240190828, Compound 5)
Affinity DataKd:  4.53E+4nMAssay Description:No detail is given.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
Go to US Patent