BDBM50591334 CHEMBL5191146::US20240182406, Example 3

SMILES ClC12CC3CC(CC(C1)c1ccccc31)(C2)NC(=O)NC1CCN(CC1)C(=O)C1CCOCC1

InChI Key InChIKey=FZXSDMYEPKMPLZ-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50591334   

TargetBifunctional epoxide hydrolase 2(Human)
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50591334(CHEMBL5191146 | US20240182406, Example 3)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of recombinant human sEH using Nonfluorescent Cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl] carbonate as subs...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBifunctional epoxide hydrolase 2(Mouse)
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50591334(CHEMBL5191146 | US20240182406, Example 3)
Affinity DataIC50: 1nMAssay Description:Inhibition of mouse sEH in using using Nonfluorescent Cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl] carbonate as substra...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50591334(CHEMBL5191146 | US20240182406, Example 3)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human recombinant LOX-5 using arachidonic acid and ATP as substrate preincubated for 10 mins followed by substrate addition and measure...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProstaglandin G/H synthase 2(Human)
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50591334(CHEMBL5191146 | US20240182406, Example 3)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant COX-2 using Arachidonic acid as substrate incubated for 5 minsMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetEpoxide hydrolase 1(Human)
Universitat De Barcelona

US Patent
LigandPNGBDBM50591334(CHEMBL5191146 | US20240182406, Example 3)
Affinity DataIC50: 0.400nMAssay Description:The fluorescent assay was used with purified recombinant human or mouse sEH proteins. The enzymes were incubated at 30° C. with the inhibitors ([I]fi...More data for this Ligand-Target Pair
In DepthDetails
US Patent