BDBM5059 1,2,4-Oxadiazole Analogue 4d::4-[(2S)-2-{[(1S)-3-carbamoyl-1-{3-[(4-chlorophenyl)methyl]-1,2,4-oxadiazol-5-yl}propyl]carbamoyl}-2-acetamidoethyl]phenoxyphosphonic acid

SMILES CC(=O)N[C@@H](Cc1ccc(OP(O)(O)=O)cc1)C(=O)N[C@@H](CCC(N)=O)c1nc(Cc2ccc(Cl)cc2)no1

InChI Key InChIKey=VZQXIGAXDCJZAG-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 5059   

TargetTyrosine-protein kinase ZAP-70(Human)
Ariad Pharmaceuticals

LigandPNGBDBM5059(4-[(2S)-2-{[(1S)-3-carbamoyl-1-{3-[(4-chlorophenyl...)
Affinity DataIC50: 2.60E+4nMpH: 7.4 T: 2°CAssay Description:Fluorescence polarization competitive binding assays were used to measure the IC50s of compounds binding to the different SH2 domains. The difference...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2005
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Ariad Pharmaceuticals

LigandPNGBDBM5059(4-[(2S)-2-{[(1S)-3-carbamoyl-1-{3-[(4-chlorophenyl...)
Affinity DataIC50: 2.05E+5nMpH: 7.4 T: 2°CAssay Description:Fluorescence polarization competitive binding assays were used to measure the IC50s of compounds binding to the different SH2 domains. The difference...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2005
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Ariad Pharmaceuticals

LigandPNGBDBM5059(4-[(2S)-2-{[(1S)-3-carbamoyl-1-{3-[(4-chlorophenyl...)
Affinity DataIC50: 5.00E+5nMpH: 7.4 T: 2°CAssay Description:Fluorescence polarization competitive binding assays were used to measure the IC50s of compounds binding to the different SH2 domains. The difference...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2005
Entry Details Article
PubMed