BDBM50588767 CHEMBL5172121

SMILES CCNC(=O)c1cncc(c1)-c1cnn2cc(-c3cnn(CC)c3)c(O[C@H]3CCOC3)nc12

InChI Key InChIKey=CCVQDAVSKDENJO-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50588767   

TargetFibroblast growth factor receptor 3(Human)
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM50588767(CHEMBL5172121)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of N-terminal His-Avi tagged recombinant human FGFR3 (447 to 761 residues) expressed in an Sf9 infected baculovirus expression system usin...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetFibroblast growth factor receptor 1(Human)
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM50588767(CHEMBL5172121)
Affinity DataIC50: 54nMAssay Description:Inhibition of recombinant human FGFR1 using biotin-EQEDEPEGDYFEWLE-amide as substrate preincubated for 5 to 10 mins followed by substrate addition an...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetFibroblast growth factor receptor 3(Mouse)
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM50588767(CHEMBL5172121)
Affinity DataIC50: 22nMAssay Description:Inhibition of TEL-FGFR3 in mouse BaF3 cells incubated for 125 mins by plate reader analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCytochrome P450 3A4(Human)
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM50588767(CHEMBL5172121)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of human liver microsomes CYP3A4 using midazolam or testosterone as substrate in presence of NADPH regenerating system by LC-MS/MS analysi...More data for this Ligand-Target Pair
In DepthDetails
PubMed