BDBM50587785 CHEMBL5178368

SMILES CCCNc1ccc2ncc(-c3ccc4[nH]ncc4c3)n2n1

InChI Key InChIKey=CZZCAOGIEGXMBZ-UHFFFAOYSA-N

Data  10 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50587785   

TargetSerine/threonine-protein kinase haspin(Human)
Cha University

Curated by ChEMBL
LigandPNGBDBM50587785(CHEMBL5178368)
Affinity DataIC50: 2nMAssay Description:Inhibition of haspin (unknown origin) by FRET assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
University of Clermont Auvergne

Curated by ChEMBL
LigandPNGBDBM50587785(CHEMBL5178368)
Affinity DataIC50: 29nMAssay Description:Inhibition of recombinant human PIM1 expressed in bacterial expression system using histone H1 as substrate measured after 30 mins in presence of ATP...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSerine/threonine-protein kinase haspin(Human)
Cha University

Curated by ChEMBL
LigandPNGBDBM50587785(CHEMBL5178368)
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant human Haspin (470 to 798 residues) expressed in bacterial expression system using ARTKQTARKSTGGKAPRKQLA as substrate measur...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetDual specificity protein kinase CLK1(Mouse)
University of Clermont Auvergne

Curated by ChEMBL
LigandPNGBDBM50587785(CHEMBL5178368)
Affinity DataIC50: 8nMAssay Description:Inhibition of recombinant mouse CLK1 expressed in bacteria using GRSRSRSRSRSR as substrate in presence of ATP measured after 30 mins by ADP-Glo assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Rat)
University of Clermont Auvergne

Curated by ChEMBL
LigandPNGBDBM50587785(CHEMBL5178368)
Affinity DataIC50: 13nMAssay Description:Inhibition of recombinant rat DYRK1A (1 to 499 residues ) expressed in bacterial expression system using KKISGRLSPIMTEQ as substrate measured after 3...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
University of Clermont Auvergne

Curated by ChEMBL
LigandPNGBDBM50587785(CHEMBL5178368)
Affinity DataIC50: 53nMAssay Description:Inhibition of human recombinant GSK3beta expressed in baculovirus in Sf9 insect cells using YRRAAVPPSPSLSRHSSPHQSpEDEEE as substrate measured after 3...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCasein kinase I isoform epsilon(Human)
University of Clermont Auvergne

Curated by ChEMBL
LigandPNGBDBM50587785(CHEMBL5178368)
Affinity DataIC50: 99nMAssay Description:Inhibition of human recombinant CK1 epsilon expressed in baculovirus in sf9 insect cells using RRKHAAIGSpAYSITA as substrate in presence of ATP measu...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
University of Clermont Auvergne

Curated by ChEMBL
LigandPNGBDBM50587785(CHEMBL5178368)
Affinity DataIC50: 41nMAssay Description:Inhibition of human recombinant CDK5/p25 expressed in bacterial expression system using histone H1 as substrate in presence of ATP at measured after ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase ABL1(Human)
University of Clermont Auvergne

Curated by ChEMBL
LigandPNGBDBM50587785(CHEMBL5178368)
Affinity DataIC50: 162nMAssay Description:Inhibition of human recombinant ABL1 expressed in baculovirus sf9 insect cells using EAIYAAPFAKKK as substrate measured after 30 mins in presence of ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase JAK3(Human)
University of Clermont Auvergne

Curated by ChEMBL
LigandPNGBDBM50587785(CHEMBL5178368)
Affinity DataIC50: 119nMAssay Description:Inhibition of human recombinant JAK3 expressed in baculovirus sf9 insect cells using GGEEEEYFELVKKKK as substrate measured after 30 mins in presence ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSerine/threonine-protein kinase haspin(Human)
Cha University

Curated by ChEMBL
LigandPNGBDBM50587785(CHEMBL5178368)
Affinity DataKd: <0.170nMAssay Description:Inhibition of haspin (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails
PubMed