BDBM50587738 CHEMBL5185871

SMILES C[C@H]1CN(C[C@@H](C)N1)c1ccc(cn1)C(=O)Nc1ccc(Cl)c(NC(=O)c2cccc(Cl)c2)c1

InChI Key InChIKey=MUDSTASCLPLIBL-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50587738   

TargetSmoothened homolog(Human)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50587738(CHEMBL5185871)
Affinity DataIC50: 300nMAssay Description:Inhibition of wild type Smo (unknown origin) expressed in mouse C3H 10T1/2 cells cotransfected with Gli reporter gene assessed as Gli luciferase acti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetSmoothened homolog(Human)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50587738(CHEMBL5185871)
Affinity DataIC50: 700nMAssay Description:Inhibition of Smo D473H mutant (unknown origin) expressed in mouse C3H 10T1/2 cells cotransfected with Gli reporter gene assessed as Gli luciferase a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetSmoothened homolog(Human)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50587738(CHEMBL5185871)
Affinity DataIC50: 8nMAssay Description:Inhibition of endogenous human Smo overexpressed in mouse C3H 10T1/2 cells cotransfected with Gli reporter gene assessed as Gli luciferase activity b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetSmoothened homolog(Mouse)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50587738(CHEMBL5185871)
Affinity DataIC50: 27nMAssay Description:Inhibition of endogenous mouse Smo overexpressed in mouse C3H 10T1/2 cells cotransfected with Gli reporter gene assessed as Gli luciferase activity b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed