BDBM50587654 CHEMBL5181796

SMILES CC(C)CN1CC(Oc2ccc(cc12)C(O)=O)c1ccc(Cl)cc1Cl

InChI Key InChIKey=MJRWHAZXYGFMKD-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50587654   

TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Amgen

Curated by ChEMBL

LigandBDBM50587654(CHEMBL5181796)Copy SMILESCopy InChI

Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of recombinant His6-tagged human MCL1 (171 to 327 residues) expressed in Escherichia coli and TAMRA labeled Bim BH3 peptide interaction us...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/18/2023
Entry Details
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TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Amgen

Curated by ChEMBL

LigandBDBM50587654(CHEMBL5181796)Copy SMILESCopy InChI

Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of TAMRA-labeled BIM-BH3 peptide binding to 6His-tagged human recombinant Mcl-1 (171 to 327 residues) incubated for 120 mins by fluorescen...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
4/21/2024
Entry Details
Copy Entry DOIPubMed
Copy Rxn URL