BDBM50587625 CHEMBL5199374

SMILES COc1cc(CCc2cc(n[nH]2)-c2nc3ccc(cc3[nH]2)N2CCN(C)CC2)cc(OC)c1

InChI Key InChIKey=QHCGPJPIPKDWAT-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50587625   

TargetFibroblast growth factor receptor 2(Human)
Celon Pharma

Curated by ChEMBL
LigandPNGBDBM50587625(CHEMBL5199374)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human FGFR2 (399 to 821 residues) expressed in baculovirus expression system using IGF-1Rtide peptide...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetFibroblast growth factor receptor 3(Human)
Celon Pharma

Curated by ChEMBL
LigandPNGBDBM50587625(CHEMBL5199374)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged FGFR3 (436 to 806 residues) expressed in baculovirus expression system using IGF-1Rtide peptide...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Celon Pharma

Curated by ChEMBL
LigandPNGBDBM50587625(CHEMBL5199374)
Affinity DataIC50: 66nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human KDR (790 to 1356 residues) expressed in baculovirus expression system using IGF-1Rtide peptide ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetFibroblast growth factor receptor 4(Human)
Celon Pharma

Curated by ChEMBL
LigandPNGBDBM50587625(CHEMBL5199374)
Affinity DataIC50: 88nMAssay Description:Inhibition of FGFR4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Celon Pharma

Curated by ChEMBL
LigandPNGBDBM50587625(CHEMBL5199374)
Affinity DataIC50: 173nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetAurora kinase A(Human)
Celon Pharma

Curated by ChEMBL
LigandPNGBDBM50587625(CHEMBL5199374)
Affinity DataIC50: 198nMAssay Description:Inhibition of Aurora A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Celon Pharma

Curated by ChEMBL
LigandPNGBDBM50587625(CHEMBL5199374)
Affinity DataIC50: 343nMAssay Description:Inhibition of PDGFRb (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Celon Pharma

Curated by ChEMBL
LigandPNGBDBM50587625(CHEMBL5199374)
Affinity DataIC50: 1.03E+3nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetFibroblast growth factor receptor 1(Human)
Celon Pharma

Curated by ChEMBL
LigandPNGBDBM50587625(CHEMBL5199374)
Affinity DataIC50: 0.75nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human FGFR1 (398 to 822 residues) expressed in baculovirus expression system using IGF-1Rtide peptide...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed