BDBM50585787 CHEMBL5093798

SMILES Cn1cc(CN2CC3(C2)CCN(C3)c2ncc(cn2)C(=O)NO)c2ccc(cc12)C#N

InChI Key InChIKey=WBVFFDSDELAGSY-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50585787   

TargetHistone deacetylase 2(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50585787(CHEMBL5093798)
Affinity DataIC50: 5.10nMAssay Description:Inhibition of recombinant human full length C-terminal His tagged HDAC2 (1 to 488 residues) expressed in baculovirus-infected Sf9 insect cells using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50585787(CHEMBL5093798)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of recombinant human full length C-terminal His/FLAG tagged HDAC1 (1 to 482 residues) expressed in baculovirus-infected Sf9 cells using Ac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetHistone deacetylase 3(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50585787(CHEMBL5093798)
Affinity DataIC50: 5.20nMAssay Description:Inhibition of human C-terminal His tagged HDAC3 (1 to 428 residues) expressed in baculovirus-infected Sf9 cells using Ac-peptide as substrate incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50585787(CHEMBL5093798)
Affinity DataIC50: 86nMAssay Description:Inhibition of recombinant human full length N-terminal GST tagged HDAC6 (1 to 1215 residues) expressed in baculovirus-infected Sf9 cells using Ac-pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50585787(CHEMBL5093798)
Affinity DataIC50: 30nMAssay Description:Inhibition of recombinant human full length C-terminal His-tagged HDAC8 expressed in baculovirus-infected Sf9 insect cells using Ac-peptide as substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50585787(CHEMBL5093798)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human C-terminal His-tagged SIRT2 (50 to 356 residues) expressed in Escherichia coli using Ac-peptide as substrate incubated for 4 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed