BDBM50585516 CHEMBL5075673

SMILES [H][C@]12CC[C@]([H])(C[C@H](C1)Nc1cc(cc3cnc(N)nc13)-c1cc(F)c(O)cc1CC)N2

InChI Key InChIKey=OOSFLRHKSBTYIX-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50585516   

TargetAurora kinase B(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50585516(CHEMBL5075673)
Affinity DataIC50: 2.51E+3nMAssay Description:Inhibition of 6His tagged AURORA B (1 to 344 residue) (unknown origin) using 5FAM-GRTGRRNSI-NH2 as substrate preincubated for 30 mins followed by sub...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50585516(CHEMBL5075673)
Affinity DataIC50: 0.631nMAssay Description:Inhibition of GST-fused human JAK1 (854 to 1154 residues) expressed in insect cells using ULight-JAK-1 Tyr1023 peptide as substrate preincubated for ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50585516(CHEMBL5075673)
Affinity DataIC50: 2nMAssay Description:Inhibition of GST-tagged recombinant human JAK2 (808 to 1132 residues) expressed in baculovirus expression system using ULight-JAK-1 Tyr1023 peptide ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50585516(CHEMBL5075673)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of GST-fused human JAK3 (810 to 1100 residues) expressed in insect cells using ULight-JAK-1 Tyr1023 peptide as substrate preincubated for ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50585516(CHEMBL5075673)
Affinity DataIC50: 100nMAssay Description:Inhibition of human TYK2 (888 to 1178 residues) expressed in insect cells using ULight-JAK-1 Tyr1023 peptide as substrate preincubated for 30 mins fo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50585516(CHEMBL5075673)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human GST/6His-tagged VEGFR2 using Biotin-aminohexyl-EEEEYFELVAKKKK-NH2 as substrate incubated for 90 mins in presence of ATP by TR-FRE...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetJAK3/JAK1(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50585516(CHEMBL5075673)
Affinity DataIC50: 126nMAssay Description:Inhibition of JAK1/JAK3 signalling in human PBMC assessed as inhibition of IL-2 stimulated IFN-gamma release incubated for 1 hr followed by IL-2 stim...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50585516(CHEMBL5075673)
Affinity DataIC50: 40nMAssay Description:Inhibition of JAK1/JAK2/TYK1 in human lung fibroblast cells assessed as IL-13 induced eotaxin production incubated for 20 to 24 hrs by MSD assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed