BDBM50583442 CHEMBL5077096

SMILES Cc1cnc(Nc2cnn(c2)C(F)F)nc1N1CCC2(CCNC2=O)CC1

InChI Key InChIKey=ROOUYRXCMOACDH-UHFFFAOYSA-N

Data  15 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50583442   

TargetTyrosine-protein kinase JAK1(Human)
Sichuan University and Collaborative Innovation Center of Biotherapy

Curated by ChEMBL
LigandPNGBDBM50583442(CHEMBL5077096)
Affinity DataIC50: 37nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Sichuan University and Collaborative Innovation Center of Biotherapy

Curated by ChEMBL
LigandPNGBDBM50583442(CHEMBL5077096)
Affinity DataIC50: 140nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Sichuan University and Collaborative Innovation Center of Biotherapy

Curated by ChEMBL
LigandPNGBDBM50583442(CHEMBL5077096)
Affinity DataIC50: 362nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Sichuan University and Collaborative Innovation Center of Biotherapy

Curated by ChEMBL
LigandPNGBDBM50583442(CHEMBL5077096)
Affinity DataIC50: 6nMAssay Description:Inhibition of TYK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2/Tyrosine-protein kinase JAK1(Human)
Sichuan University and Collaborative Innovation Center of Biotherapy

Curated by ChEMBL
LigandPNGBDBM50583442(CHEMBL5077096)
Affinity DataIC50: 22nMAssay Description:Inhibition of TYK2/JAK1 signalling in human PBMC assessed as inhibition of INF-alpha stimulated phosphorylation of STAT3 preincubated for 60 mins fol...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2/Tyrosine-protein kinase JAK1(Human)
Sichuan University and Collaborative Innovation Center of Biotherapy

Curated by ChEMBL
LigandPNGBDBM50583442(CHEMBL5077096)
Affinity DataIC50: 65nMAssay Description:Inhibition of TYK2/JAK1 signalling in human PBMC assessed as inhibition of IL-10 stimulated phosphorylation of STAT3 preincubated for 60 mins followe...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetJAK3/JAK1(Human)
Sichuan University and Collaborative Innovation Center of Biotherapy

Curated by ChEMBL
LigandPNGBDBM50583442(CHEMBL5077096)
Affinity DataIC50: 296nMAssay Description:Inhibition of JAK1/JAK3 signalling in human PBMC assessed as inhibition of IL-21 stimulated phosphorylation of STAT3 preincubated for 60 mins followe...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2/Tyrosine-protein kinase JAK2(Human)
Sichuan University and Collaborative Innovation Center of Biotherapy

Curated by ChEMBL
LigandPNGBDBM50583442(CHEMBL5077096)
Affinity DataIC50: 299nMAssay Description:Inhibition of JAK2/TYK2 signalling in human PBMC assessed as inhibition of IL-23 stimulated phosphorylation of STAT3 preincubated for 60 mins followe...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK1/JAK2(Human)
Sichuan University and Collaborative Innovation Center of Biotherapy

Curated by ChEMBL
LigandPNGBDBM50583442(CHEMBL5077096)
Affinity DataIC50: 1.12E+3nMAssay Description:Inhibition of JAK1/JAK2 signalling in human PBMC assessed as inhibition of IL-27 stimulated phosphorylation of STAT3 preincubated for 60 mins followe...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 1A2(Human)
Sichuan University and Collaborative Innovation Center of Biotherapy

Curated by ChEMBL
LigandPNGBDBM50583442(CHEMBL5077096)
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
Sichuan University and Collaborative Innovation Center of Biotherapy

Curated by ChEMBL
LigandPNGBDBM50583442(CHEMBL5077096)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C19(Human)
Sichuan University and Collaborative Innovation Center of Biotherapy

Curated by ChEMBL
LigandPNGBDBM50583442(CHEMBL5077096)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
Sichuan University and Collaborative Innovation Center of Biotherapy

Curated by ChEMBL
LigandPNGBDBM50583442(CHEMBL5077096)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2E1(Human)
Sichuan University and Collaborative Innovation Center of Biotherapy

Curated by ChEMBL
LigandPNGBDBM50583442(CHEMBL5077096)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP2E1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 3A4(Human)
Sichuan University and Collaborative Innovation Center of Biotherapy

Curated by ChEMBL
LigandPNGBDBM50583442(CHEMBL5077096)
Affinity DataIC50: 5.20E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed