BDBM50581480 CHEMBL5088809

SMILES COc1cc(OC)c2C[C@@H](OC(=O)c3ccc(F)c(NC(=O)c4cc(OC)c(OC)c(OC)c4)c3)[C@H](Oc2c1)c1ccc(OC)c(OC)c1

InChI Key InChIKey=OEIXJPAIZADICN-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50581480   

TargetMultidrug resistance-associated protein 1(Human)
Hong Kong Polytechnic University

Curated by ChEMBL
LigandPNGBDBM50581480(CHEMBL5088809)
Affinity DataIC50: 341nMAssay Description:Inhibition of MRP1 in human 2008/MRP1 cells assessed as reversal of doxorubicin resistance by measuring doxorubicin IC50 at 1 uM after 5 days by Cell...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Hong Kong Polytechnic University

Curated by ChEMBL
LigandPNGBDBM50581480(CHEMBL5088809)
Affinity DataIC50: 101nMAssay Description:Inhibition of BCRP in HEK293/R2 cells assessed as reversal of topotecan resistance by measuring topotecan IC50 at 1 uM after 5 days by Cell Titer-Glo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Hong Kong Polytechnic University

Curated by ChEMBL
LigandPNGBDBM50581480(CHEMBL5088809)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of P-glycoprotein in human LCC6MDR cells assessed as reversal fold by measuring reduction in paclitaxel by measuring paclitaxel IC50 at 1 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed