BDBM50581207 CHEMBL5074216

SMILES COc1ccc(cc1OC)[C@H](Cc1c(Cl)c[n+]([O-])cc1Cl)OC(=O)c1ccc(CNC(C(=O)O[C@@H]2CCN(C)C2)c2ccccc2)s1

InChI Key InChIKey=TVXXBTHJBOIRBM-UHFFFAOYSA-N

Data  2 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50581207   

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50581207(CHEMBL5074216)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of human recombinant PDE4B2 assessed as reduction in cAMP level incubated for 2 hrs by LANCE Ultra cAMP TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50581207(CHEMBL5074216)
Affinity DataIC50: 3.16nMAssay Description:Inhibition of human recombinant PDE4B2 assessed as reduction in cAMP level incubated for 2 hrs by LANCE Ultra cAMP TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Rat)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50581207(CHEMBL5074216)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at muscarinic M3 receptor in rat trachea assessed as inhibition of carbachol-induced contractionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Rat)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50581207(CHEMBL5074216)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at muscarinic M3 receptor in rat trachea assessed as inhibition of carbachol-induced contractionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50581207(CHEMBL5074216)
Affinity DataKi:  7.90nMAssay Description:Displacement of [3H]-N-methyl Scopolamine Chloride from human M3 receptor membranes incubated for 2 hrs by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50581207(CHEMBL5074216)
Affinity DataKi:  7.94nMAssay Description:Displacement of [3H]-N-methyl Scopolamine Chloride from human M3 receptor membranes incubated for 2 hrs by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed