BDBM50580630 CHEMBL5080175::US20240150297, Compound 18a

SMILES Cc1n[nH]c(C)c1N1CCN(CC1)c1cc(ccc1F)C(O)=O

InChI Key InChIKey=LRSWBFBFWVRRKW-UHFFFAOYSA-N

Data  5 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50580630   

TargetTransthyretin(Human)
Albany College of Pharmacy and Health Sciences

Curated by ChEMBL
LigandPNGBDBM50580630(CHEMBL5080175 | US20240150297, Compound 18a)
Affinity DataIC50: 220nMAssay Description:Binding affinity to human plasma TTR tetramer assessed as displacement of diclofenac-coupled FITC by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetRetinol-binding protein 4(Human)
Albany College of Pharmacy and Health Sciences

Curated by ChEMBL
LigandPNGBDBM50580630(CHEMBL5080175 | US20240150297, Compound 18a)
Affinity DataIC50: 3.00E+3nMAssay Description:Displacement of [3H]-all trans retinol from human urine biotinylated RBP4 incubated for 16 hrs measured by Scintillation Proximity AssayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Albany College of Pharmacy and Health Sciences

Curated by ChEMBL
LigandPNGBDBM50580630(CHEMBL5080175 | US20240150297, Compound 18a)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Albany College of Pharmacy and Health Sciences

Curated by ChEMBL
LigandPNGBDBM50580630(CHEMBL5080175 | US20240150297, Compound 18a)
Affinity DataEC50: >3.00E+4nMAssay Description:Activity at PPARgamma (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetTransthyretin(Human)
Albany College of Pharmacy and Health Sciences

Curated by ChEMBL
LigandPNGBDBM50580630(CHEMBL5080175 | US20240150297, Compound 18a)
Affinity DataIC50: 220nMAssay Description:Compound binding to TTR was assessed in the fluorescence polarization assay. The assay measured competitive displacement of the fluorescent probe, FI...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
Go to US Patent

TargetAT-rich interactive domain-containing protein 4A(Human)
Columbia University

US Patent
LigandPNGBDBM50580630(CHEMBL5080175 | US20240150297, Compound 18a)
Affinity DataIC50: 3.00E+3nMAssay Description:In vitro binding of compounds to RBP4. Compound binding to RBP4 was assessed in the radiometric scintillation proximity (SPA) assay that was previous...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
Go to US Patent