BDBM50579668 CHEMBL5091438

SMILES C[C@@H](C1CC1)N1Cc2cc-3cc(c2C1=O)S(=O)(=O)NCCOCCNC(=O)c1cccc(Nc2nc(C)c-3s2)n1

InChI Key InChIKey=KDSLANAJQYLHMO-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50579668   

LigandPNGBDBM50579668(CHEMBL5091438)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of recombinant human PI3Kgamma assessed as reduction in ADP production using Dic8-PIP2 as substrate pre-treated for 15 mins followed by su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
LigandPNGBDBM50579668(CHEMBL5091438)
Affinity DataIC50: 0.631nMAssay Description:Inhibition of recombinant human PI3Kdelta assessed as reduction in ADP production using Dic8-PIP2 as substrate pre-treated for 15 mins followed by su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
LigandPNGBDBM50579668(CHEMBL5091438)
Affinity DataIC50: 0.794nMAssay Description:Inhibition of PI3Kgamma in C5a-stimulated mouse RAW 264 cells assessed as inhibition of AKT phosphorylation at Ser473 residue Pretreated for 15 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
LigandPNGBDBM50579668(CHEMBL5091438)
Affinity DataIC50: 2nMAssay Description:Inhibition of PI3Kdelta in anti-IgM-stimulated human JeKo-1 cells assessed as inhibition of AKT phosphorylation at Ser473 residue incubated for 60 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
LigandPNGBDBM50579668(CHEMBL5091438)
Affinity DataIC50: 40nMAssay Description:Inhibition of recombinant human PI3Kalpha assessed as reduction in ADP production using Dic8-PIP2 as substrate pre-treated for 15 mins followed by su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
LigandPNGBDBM50579668(CHEMBL5091438)
Affinity DataIC50: 316nMAssay Description:Inhibition of PIK3C2A (unknown origin) assessed as reduction in substrate phosphorylation by FRET Adapta assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
LigandPNGBDBM50579668(CHEMBL5091438)
Affinity DataIC50: 0.794nMAssay Description:Inhibition of PIK3C2B (unknown origin) assessed as reduction in substrate phosphorylation by FRET Adapta assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
LigandPNGBDBM50579668(CHEMBL5091438)
Affinity DataIC50: 25nMAssay Description:Inhibition of PIK3C3 (unknown origin) assessed as reduction in substrate phosphorylation by FRET Adapta assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetPhosphatidylinositol 4-kinase alpha(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50579668(CHEMBL5091438)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PI4KA (unknown origin) assessed as reduction in substrate phosphorylation by FRET Adapta assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetPhosphatidylinositol 4-kinase beta(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50579668(CHEMBL5091438)
Affinity DataIC50: 20nMAssay Description:Inhibition of PI4KB (unknown origin) assessed as reduction in substrate phosphorylation by FRET Adapta assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed