BDBM50579499 CHEMBL4847875

SMILES CN(C)c1ccc2c(Oc3ccc(NC(=O)NCc4ccc(nc4)C(F)(F)F)cc3)ncnc2c1

InChI Key InChIKey=ORYMWWSJZRCUSV-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50579499   

TargetMacrophage colony-stimulating factor 1 receptor(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50579499(CHEMBL4847875)
Affinity DataIC50: 14nMAssay Description:Inhibition of human recombinant GST-CSF1R (residues L534 to C972) expressed in Sf9 insect cells using poly(Glu,Tyr) as substrate incubated for 20 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2022
Entry Details Article
PubMed
TargetAurora kinase A(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50579499(CHEMBL4847875)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant GST-AURKA (residues Ser123 to Ser401) (unknown origin) expressed in Sf9 insect cells using tetra(-LRRASLG) peptide as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2022
Entry Details Article
PubMed
TargetAurora kinase B(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50579499(CHEMBL4847875)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of human recombinant full length GST-AURKB using tetra(-LRRASLG) peptide as substrate incubated for 20 mins by ATP Kinase Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2022
Entry Details Article
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50579499(CHEMBL4847875)
Affinity DataIC50: 0.530nMAssay Description:Inhibition of wild-type human partial length CSF1R (I564 to S939 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2022
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50579499(CHEMBL4847875)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human c-Kit by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2022
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50579499(CHEMBL4847875)
Affinity DataIC50: 53nMAssay Description:Inhibition of wild-type human partial length PDGFRalpha (V575 to D1002 residues) expressed in mammalian expression system by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2022
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50579499(CHEMBL4847875)
Affinity DataIC50: 32nMAssay Description:Inhibition of wild-type human partial length PDGFRbeta (V582 to Y1009 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2022
Entry Details Article
PubMed
TargetEpithelial discoidin domain-containing receptor 1(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50579499(CHEMBL4847875)
Affinity DataIC50: 60nMAssay Description:Inhibition of wild-type human partial length DDR1 (R565 to V876 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2022
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50579499(CHEMBL4847875)
Affinity DataIC50: 64nMAssay Description:Inhibition of wild-type human partial length FLT3 (V592 to Y969 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2022
Entry Details Article
PubMed
TargetAurora kinase B(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50579499(CHEMBL4847875)
Affinity DataIC50: 226nMAssay Description:Inhibition of wild-type human partial length AURKB (D25 to A303 residues) expressed in mammalian expression system by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 3(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50579499(CHEMBL4847875)
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of wild-type human full length PAK3 (M1 to R544 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2022
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50579499(CHEMBL4847875)
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of wild-type human partial length VEGFR2 (R787 to P1253 residues) expressed in mammalian expression system by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2022
Entry Details Article
PubMed