BDBM50576426 CHEMBL4854042

SMILES CNC(=O)c1cc(C(=O)N[C@H]2CC[C@H](O)CC2)n(n1)[C@@H](C)c1ccccc1

InChI Key InChIKey=LEXSRVMWXAFLMV-UHFFFAOYSA-N

Data  9 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50576426   

TargetBromodomain-containing protein 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50576426(CHEMBL4854042)
Affinity DataIC50: 251nMAssay Description:Binding affinity to 6His-Thr-BRD2 (1 to 473 residues) BD2 domain Y386A or Y113A mutant (unknown origin) incubated for 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBromodomain-containing protein 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50576426(CHEMBL4854042)
Affinity DataIC50: 2.51E+4nMAssay Description:Binding affinity to 6His-Thr-BRD2 (1 to 473 residues) BD1 domain (unknown origin) incubated for 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBromodomain-containing protein 3(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50576426(CHEMBL4854042)
Affinity DataIC50: 79nMAssay Description:Binding affinity to 6His-Thr-BRD3 (1 to 435 residues) BD2 domain Y348A or Y73A mutant (unknown origin) incubated for 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetBromodomain-containing protein 3(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50576426(CHEMBL4854042)
Affinity DataIC50: 2.51E+4nMAssay Description:Binding affinity to 6His-Thr-BRD3 (1 to 435 residues) BD1 domain (unknown origin) incubated for 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetBromodomain testis-specific protein(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50576426(CHEMBL4854042)
Affinity DataIC50: 79nMAssay Description:Binding affinity to 6His-FLAG-Tev-BRDT (1 to 397 residues) BD2 domain Y309A or Y66A mutant (unknown origin) incubated for 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetBromodomain testis-specific protein(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50576426(CHEMBL4854042)
Affinity DataIC50: 5.01E+4nMAssay Description:Binding affinity to 6His-FLAG-Tev-BRDT (1 to 397 residues) BD1 domain (unknown origin) incubated for 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50576426(CHEMBL4854042)
Affinity DataIC50: 3.98E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin) assessed as MDI shiftMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50576426(CHEMBL4854042)
Affinity DataIC50: 5.01E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetBile salt export pump(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50576426(CHEMBL4854042)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of BSEP (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed