BDBM50576042 CHEMBL4863048

SMILES CC(C)(C)OC(=O)c1ccc(CN2CC(Oc3ccccc23)C(N)=O)cc1

InChI Key InChIKey=WVEAWXYDUUDAQS-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50576042   

TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Max Planck Institute of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50576042(CHEMBL4863048)
Affinity DataIC50: 2.01E+4nMAssay Description:Inhibition of His6-tagged SIRT1 (unknown origin) expressed in Escherichia coli BL21 (DE3) preincubated for 15 mins followed by NAD+ addition and meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Max Planck Institute of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50576042(CHEMBL4863048)
Affinity DataIC50: 4.20E+4nMAssay Description:Inhibition of His6-tagged/TEV fused SIRT2 (unknown origin) expressed in Escherichia coli BL21 (DE3) preincubated for 15 mins followed by NAD+ additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-3, mitochondrial(Human)
Max Planck Institute of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50576042(CHEMBL4863048)
Affinity DataIC50: 6.00E+4nMAssay Description:Inhibition of His6-tagged/TEV fused SIRT3 (unknown origin) expressed in Escherichia coli BL21 (DE3) preincubated for 15 mins followed by NAD+ additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed