BDBM50574707 CHEMBL4860202

SMILES CS(=O)(=O)c1nccc(n1)-c1c(nc2sccn12)-c1cccc(OCc2ccccc2)c1

InChI Key InChIKey=DQOWVAQFOQHAFL-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50574707   

TargetEpidermal growth factor receptor(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50574707(CHEMBL4860202)
Affinity DataIC50: 9.92E+3nMAssay Description:Inhibition of EGFR (unknown origin) incubated for 40 mins in presence of Mg/ATP mix by [gamma p33]-ATP based scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-4(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50574707(CHEMBL4860202)
Affinity DataIC50: 15nMAssay Description:Inhibition of ErbB4 (unknown origin) incubated for 40 mins in presence of Mg/ATP mix by [gamma p33]-ATP based scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50574707(CHEMBL4860202)
Affinity DataIC50: 8.35E+3nMAssay Description:Inhibition of JAK3 (unknown origin) incubated for 40 mins in presence of Mg/ATP mix by [gamma p33]-ATP based scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50574707(CHEMBL4860202)
Affinity DataIC50: 5.20E+3nMAssay Description:Inhibition of JNK3 (unknown origin) incubated for 40 mins in presence of Mg/ATP mix by [gamma p33]-ATP based scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-4(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50574707(CHEMBL4860202)
Affinity DataIC50: 3.30nMAssay Description:Inhibition of ErbB4 in human T47D cells assessed as suppression of neuregulin 1-induced autophosphorylation incubated for 90 mins by sandwich ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50574707(CHEMBL4860202)
Affinity DataIC50: 1.24E+4nMAssay Description:Inhibition of human ERG incubated for 3 hrs by competitive fluorescence tracer binding based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50574707(CHEMBL4860202)
Affinity DataIC50: 9.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin) using EOMCC as a substrate incubated for 20 mins by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50574707(CHEMBL4860202)
Affinity DataIC50: 1.78E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin) using BOMCC as a substrate incubated for 20 mins by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50574707(CHEMBL4860202)
Affinity DataIC50: 1.32E+4nMAssay Description:Inhibition of BRAF V600E mutant (unknown origin) incubated for 40 mins in presence of Mg/ATP mix by [gamma p33]-ATP based scintillation counting meth...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed