BDBM50573682 CHEMBL4872886

SMILES CC(C)C[C@@H](N)C(=O)Nc1ccc(-c2cnco2)c(OC(F)F)c1

InChI Key InChIKey=GCTFTMWXZFLTRR-UHFFFAOYSA-N

Data  20 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 50573682   

TargetcAMP-dependent protein kinase catalytic subunit PRKX(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50573682(CHEMBL4872886)
Affinity DataIC50: 326nMAssay Description:Inhibition of wild-type human partial length PRKX (M1 to F358 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetAP2-associated protein kinase 1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50573682(CHEMBL4872886)
Affinity DataIC50: 12nMAssay Description:Inhibition of bacterially expressed GST-Xa-tagged human AAK1 using 5-FAM-labelled Aha-KEEQSQITSQVTGQIGWR-NH2 peptide as substrate incubated for 3 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetAP2-associated protein kinase 1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50573682(CHEMBL4872886)
Affinity DataIC50: 51nMAssay Description:Inhibition of full length human AAK1 expressed in HEK293F incubated for 3 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetAP2-associated protein kinase 1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50573682(CHEMBL4872886)
Affinity DataIC50: 12nMAssay Description:Inhibition of recombinant human GST-Xa-tagged-AAK1 (30 to 330 residues) using (5-FAM)-Aha-KEEQSQITSQVTGQIGWR-NH2 as substrate incubated for 3 hrs in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetSodium-dependent serotonin transporter(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50573682(CHEMBL4872886)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of SERT (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50573682(CHEMBL4872886)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of NET (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50573682(CHEMBL4872886)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of kappa opioid receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50573682(CHEMBL4872886)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of mu opioid receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50573682(CHEMBL4872886)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of alpha 2C adrenergic receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetAlpha-2A adrenergic receptor(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50573682(CHEMBL4872886)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of alpha 2A adrenergic receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetAP2-associated protein kinase 1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50573682(CHEMBL4872886)
Affinity DataIC50: 12nMAssay Description:Inhibition of recombinant GST-Xa-tagged human AAK1 (30 to 330 residues) using 5-FAM-labelled Alla-KEEQSQITSQVTGQIGWR-NH2 peptide as substrate incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetProtein kinase C theta type(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50573682(CHEMBL4872886)
Affinity DataIC50: 1.33E+3nMAssay Description:Inhibition of PKCtheta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50573682(CHEMBL4872886)
Affinity DataIC50: 428nMAssay Description:Inhibition of wild-type human partial length MKNK2 (G63 to S388 residues) expressed in mammalian expression system by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50573682(CHEMBL4872886)
Affinity DataIC50: 507nMAssay Description:Inhibition of wild-type human full length MKNK1 (M1 to L424 residues) expressed in mammalian expression system by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase haspin(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50573682(CHEMBL4872886)
Affinity DataIC50: 922nMAssay Description:Inhibition of wild-type human partial length HASPIN (I452 to K798 residues) expressed in mammalian expression system by Kinomescan method relative to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetCyclin-G-associated kinase(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50573682(CHEMBL4872886)
Affinity DataIC50: 1.06E+3nMAssay Description:Inhibition of wild-type human partial length GAK (G13 to Y338 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetCitron Rho-interacting kinase(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50573682(CHEMBL4872886)
Affinity DataIC50: 120nMAssay Description:Inhibition of CRIK (unknown origin) by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetDual specificity protein kinase CLK4(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50573682(CHEMBL4872886)
Affinity DataIC50: 1.93E+3nMAssay Description:Inhibition of wild-type human partial length CLK4 (R135 to K481 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetBMP-2-inducible protein kinase(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50573682(CHEMBL4872886)
Affinity DataIC50: 120nMAssay Description:Inhibition of wild-type human partial length BIKE (S34 to N329 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetAP2-associated protein kinase 1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50573682(CHEMBL4872886)
Affinity DataIC50: 51nMAssay Description:Inhibition of human AAK1 expressed in HEK293 cells assessed as suppression of AP2 phosphorylation measured after 3 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed