BDBM50573044 CHEMBL4873647

SMILES CC(F)(F)COc1ncncc1CNc1ncc(C#N)c(N[C@@H]2CC[C@H](O)C(C)(C)C2)n1

InChI Key InChIKey=FMKGJQHNYMWDFJ-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50573044   

TargetProtein kinase C theta type(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50573044(CHEMBL4873647)
Affinity DataIC50: 8nMAssay Description:Inhibition of PKA-theta (unknown origin) using Fam-labelled S6-derived peptide incubated for 2 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetProtein kinase C delta type(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50573044(CHEMBL4873647)
Affinity DataIC50: 4.40E+3nMAssay Description:Inhibition of PKA-delta (unknown origin) using Fam-labelled S6-derived peptide incubated for 2 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50573044(CHEMBL4873647)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50573044(CHEMBL4873647)
Affinity DataIC50: 5.90E+3nMAssay Description:Inhibition of CYP2C19 in human liver microsomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50573044(CHEMBL4873647)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50573044(CHEMBL4873647)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of histamine H1 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetProtein kinase C theta type(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50573044(CHEMBL4873647)
Affinity DataIC50: 150nMAssay Description:Inhibition of PKC-theta in PBMC isolated from human leukocyte reduction system white blood cells isolated assessed as reduction in anti-CD3/CD28-stim...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetProtein kinase C theta type(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50573044(CHEMBL4873647)
Affinity DataIC50: 330nMAssay Description:Inhibition of PKC-theta in PBMC isolated from human leukocyte whole blood assessed as reduction in anti-CD3/CD28-stimulated IL-2 expression measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetProtein kinase C theta type(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50573044(CHEMBL4873647)
Affinity DataIC50: 1.03E+3nMAssay Description:Inhibition of PKC-theta in human whole blood assessed as reduction in anti-CD3/CD28-stimulated IL-2 expression measured for 20 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetProtein kinase C theta type(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50573044(CHEMBL4873647)
Affinity DataIC50: 290nMAssay Description:Inhibition of PKC-theta in human mixed lymphocyte reaction assessed as reduction in anti-CD3/CD28-stimulated IL-2 expression measured for 20 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetProtein kinase C theta type(Mouse)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50573044(CHEMBL4873647)
Affinity DataIC50: 4.31E+3nMAssay Description:Inhibition of PKC-theta in mouse whole blood assessed as reduction in anti-CD3/CD28-stimulated IL-2 expression measured for 20 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetProtein kinase C theta type(Mouse)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50573044(CHEMBL4873647)
Affinity DataIC50: 590nMAssay Description:Inhibition of PKC-theta in mouse mixed lymphocyte reaction assessed as reduction in anti-CD3/CD28-stimulated IL-2 expression measured for 20 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed