BDBM50572890 CHEMBL4877552

SMILES OC(=O)c1ccc(cc1C1CCCC1)-c1cnn2ccc(nc12)-c1ccccc1

InChI Key InChIKey=UBVFQVJPQKNVPY-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50572890   

TargetCalcium/calmodulin-dependent protein kinase kinase 2(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50572890(CHEMBL4877552)
Affinity DataIC50: 21nMAssay Description:Inhibition of human CAMKK2 using CAMKKtide as substrate assessed as residual activity by [gamma-33P]-ATP assay relative to controlMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase kinase 2(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50572890(CHEMBL4877552)
Affinity DataIC50: 190nMAssay Description:Inhibition of NanoLuc-fused CAMKK2 (unknown origin) expressed in HEK293 cells after 24 hrs by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase kinase 1(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50572890(CHEMBL4877552)
Affinity DataIC50: 238nMAssay Description:Inhibition of human CAMKK1 using CAMKKtide as substrate assessed as residual activity by [gamma-33P]-ATP assay relative to controlMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase kinase 2(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50572890(CHEMBL4877552)
Affinity DataIC50: 900nMAssay Description:Inhibition of CAMKK2 in human LNCaP C4-2 cells assessed as reduction AMPK phosphorylation at Thr172 incubated for 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed