BDBM50571471 CHEMBL4858310::US11685734, Example 213

SMILES [H][C@]12C[C@@]1([H])[C@H](Cc1ccccc1)N(C2)c1nc(cc(=O)[nH]1)N1CCOCC1

InChI Key InChIKey=KVVLNFCQHKOZRL-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50571471   

TargetSerine-protein kinase ATM(Human)
Chdi Foundation

US Patent
LigandPNGBDBM50571471(CHEMBL4858310 | US11685734, Example 213)
Affinity DataIC50: 1.10nMAssay Description:ATM: Recombinant, full length human FLAG-tagged ATM activity (Eurofins 14-933) was measured in an ELISA for p53 S15 phosphorylation, in a 384 well V-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2023
Entry Details
Go to US Patent

TargetSerine-protein kinase ATM(Human)
Chdi Foundation

US Patent
LigandPNGBDBM50571471(CHEMBL4858310 | US11685734, Example 213)
Affinity DataIC50: 130nMAssay Description:Inhibition of ATM in human U2OS cells assessed as reduction in etoposide-stimulated KAP1 phosphorylation incubated for 60 mins by immunoreactivity as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetSerine-protein kinase ATM(Human)
Chdi Foundation

US Patent
LigandPNGBDBM50571471(CHEMBL4858310 | US11685734, Example 213)
Affinity DataKi:  0.200nMAssay Description:Inhibition of full length recombinant FLAG-tagged human ATM assessed as decrease in p53 S15 phosphorylation using full length myc-tagged p53 as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
LigandPNGBDBM50571471(CHEMBL4858310 | US11685734, Example 213)
Affinity DataKi:  21nMAssay Description:Inhibition of full length recombinant GST-tagged human VPS34 expressed in baculovirus expression system using PI/PS as substrate incubated for 60 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed