BDBM50565548 CHEMBL4790998

SMILES COc1cc(OC)c2c(nc(nc2c1)-c1cc(C)c(OCCCCCC(=O)NO)c(C)c1)N1CCS(=O)(=O)CC1

InChI Key InChIKey=YRUAJZFECDBHMT-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50565548   

TargetHistone deacetylase 6(Human)
Shenzhen Technology University

Curated by ChEMBL
LigandPNGBDBM50565548(CHEMBL4790998)
Affinity DataIC50: 55nMAssay Description:Inhibition of recombinant human His-tagged HDAC6 expressed in baculovirus infected insect cells using Ac-Leu-Gly-Lys(Ac)-AMC as substrate measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Shenzhen Technology University

Curated by ChEMBL
LigandPNGBDBM50565548(CHEMBL4790998)
Affinity DataIC50: 100nMAssay Description:Inhibition of recombinant human His-tagged HDAC1 expressed in insect cells using Ac-Leu-Gly-Lys(Ac)-AMC as substrate measured after 30 mins by fluore...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
Shenzhen Technology University

Curated by ChEMBL
LigandPNGBDBM50565548(CHEMBL4790998)
Affinity DataIC50: 136nMAssay Description:Inhibition of human full-length C-terminal FLAG-tagged HDAC2 expressed in baculovirus infected Sf9 insect cells using Ac-Leu-Gly-Lys(Ac)-AMC as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetNuclear receptor corepressor 1(Human)
Shenzhen Technology University

Curated by ChEMBL
LigandPNGBDBM50565548(CHEMBL4790998)
Affinity DataIC50: 106nMAssay Description:Inhibition of recombinant human GST-fused HDAC3/NCOR1 (397 to 503 residues) expressed in baculovirus infected insect cells using Ac-Leu-Gly-Lys(Ac)-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
Shenzhen Technology University

Curated by ChEMBL
LigandPNGBDBM50565548(CHEMBL4790998)
Affinity DataIC50: 404nMAssay Description:Inhibition of recombinant human full-length C-terminal His-tagged HDAC8 expressed in baculovirus infected Sf9 insect cells using Ac-Leu-Gly-Lys(Tfa)-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetHistone deacetylase 4(Human)
Shenzhen Technology University

Curated by ChEMBL
LigandPNGBDBM50565548(CHEMBL4790998)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged HDAC4 (627 to end residues) expressed in baculovirus infected Sf9 insect cells using AcLeu-Gly-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetHistone deacetylase 5(Human)
Shenzhen Technology University

Curated by ChEMBL
LigandPNGBDBM50565548(CHEMBL4790998)
Affinity DataIC50: 688nMAssay Description:Inhibition of recombinant human full-length N-terminal GST-tagged HDAC5 expressed in baculovirus infected Sf9 insect cells using AcLeu-Gly-Lys(Tfa)-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetHistone deacetylase 7(Human)
Shenzhen Technology University

Curated by ChEMBL
LigandPNGBDBM50565548(CHEMBL4790998)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of HDAC7 (unknown origin) using AcLeu-Gly-Lys(Tfa)-AMC as substrate measured after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetHistone deacetylase 9(Human)
Shenzhen Technology University

Curated by ChEMBL
LigandPNGBDBM50565548(CHEMBL4790998)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant human full-length N-terminal GST-tagged HDAC9 (1 to 1069 residues) expressed in wheat germ expression system using Ac-Leu-G...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetPolyamine deacetylase HDAC10(Human)
Shenzhen Technology University

Curated by ChEMBL
LigandPNGBDBM50565548(CHEMBL4790998)
Affinity DataIC50: 78nMAssay Description:Inhibition of recombinant human C-terminal His-tagged HDAC10 expressed in baculovirus infected Sf9 insect cells using Ac-Arg-His-Lys(Ac)-Lys(Ac)-AMC ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetHistone deacetylase 11(Human)
Shenzhen Technology University

Curated by ChEMBL
LigandPNGBDBM50565548(CHEMBL4790998)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant human N-terminal His-tagged HDAC11 expressed in baculovirus infected Sf9 insect cells using Ac-Arg-His-Lys(Ac)-Lys(Ac)-AMC ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed