BDBM50565476 CHEMBL4780117

SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(C)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCC(=O)NCCCC[C@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccccc2)NC1=O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O

InChI Key InChIKey=CURJMMDVBCSAEU-UHFFFAOYSA-N

Data  1 IC50  1 Kd  1 Koff

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50565476   

TargetEukaryotic translation initiation factor 4E(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50565476(CHEMBL4780117)
Affinity DataIC50: 6.5nMAssay Description:Inhibition of recombinant human 10His-tagged eIF4E expressed in Escherichia coli BL21 (DE3) cells by catalytic enzyme-linked click chemistry assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50565476(CHEMBL4780117)
Affinity DataKon:  0.00690M-1s-1Assay Description:Binding affinity to recombinant human 10His-tagged eIF4E expressed in Escherichia coli BL21 (DE3) cells assessed as dissociation constant by surface ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50565476(CHEMBL4780117)
Affinity DataKd:  2.20nMAssay Description:Binding affinity to recombinant human 10His-tagged eIF4E expressed in Escherichia coli BL21 (DE3) cells assessed as binding constant by surface plasm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed