BDBM50565103 CHEMBL4777657

SMILES Nc1cc(ccn1)N1c2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2Oc2ncccc2C1=O

InChI Key InChIKey=VQVRSCPORIUCDA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50565103   

TargetCyclin-dependent kinase 8(Human)
Spanish National Cancer Research Centre (Cnio)

Curated by ChEMBL
LigandPNGBDBM50565103(CHEMBL4777657)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CDK8 in human SW-620 cells assessed as reduction in STAT1 phosphorylation at Ser727 residues measured after 8 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetCyclin-dependent kinase 8(Human)
Spanish National Cancer Research Centre (Cnio)

Curated by ChEMBL
LigandPNGBDBM50565103(CHEMBL4777657)
Affinity DataIC50: 58nMAssay Description:Inhibition of CDK8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed