BDBM50564275 CHEMBL4778367

SMILES CC(C)c1cn2c(n1)c(C(C)=O)c(C)c1cnc(Nc3ccc(cc3)N3CCNCC3)nc21

InChI Key InChIKey=DEVYXOKAXWLJRC-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50564275   

TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Shanghai Pharmaceuticals Holding

Curated by ChEMBL
LigandPNGBDBM50564275(CHEMBL4778367)
Affinity DataIC50: 23nMAssay Description:Inhibition of CDK9/cyclin T1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D3(Human)
Shanghai Pharmaceuticals Holding

Curated by ChEMBL
LigandPNGBDBM50564275(CHEMBL4778367)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of recombinant human full-length N-terminal GST-fused CDK4 (1 to 303 residues)/GST-tagged CyclinD3 (1 to 292 residues) expressed in baculo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D3(Human)
Shanghai Pharmaceuticals Holding

Curated by ChEMBL
LigandPNGBDBM50564275(CHEMBL4778367)
Affinity DataIC50: 2nMAssay Description:Inhibition of human full-length N-terminal GST tagged CDK6 (1 to 326 residues)/GST-tagged cyclinD3 (1 to 292 residues) expressed in baculovirus expre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Shanghai Pharmaceuticals Holding

Curated by ChEMBL
LigandPNGBDBM50564275(CHEMBL4778367)
Affinity DataIC50: 309nMAssay Description:Inhibition of CDK1/cyclin B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Shanghai Pharmaceuticals Holding

Curated by ChEMBL
LigandPNGBDBM50564275(CHEMBL4778367)
Affinity DataIC50: 19nMAssay Description:Inhibition of CDK2/cyclin A2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Shanghai Pharmaceuticals Holding

Curated by ChEMBL
LigandPNGBDBM50564275(CHEMBL4778367)
Affinity DataIC50: 95nMAssay Description:Inhibition of CDK7/cyclin H (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed