BDBM50562040 CHEMBL4761736

SMILES Cc1cc(ncn1)N1CC2CCC(C1)C2Nc1nc2[C@@H](CCCCn2n1)c1ccc(F)c(F)c1F

InChI Key InChIKey=XGTZKVXMDSWEOE-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50562040   

TargetPresenilin-1(Human)
Roche Innovation Center Basel

Curated by ChEMBL
LigandPNGBDBM50562040(CHEMBL4761736)
Affinity DataIC50: 17nMAssay Description:Modulatory activity of gamma secretase in human H4 cells overexpressing human APP695 K595N/M596L mutant assessed as decrease in amyloidbeta42 levels ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed