BDBM50559919 CHEMBL4782725

SMILES CC#CC(=O)Nc1cc2c(Oc3ccc(cc3)C(=O)Nc3ccccn3)ccnc2cc1OCCN1CCOCC1

InChI Key InChIKey=OPKHZFMFWCMAPS-UHFFFAOYSA-N

Data  12 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50559919   

TargetEpidermal growth factor receptor(Human)
Acerta Pharma

Curated by ChEMBL
LigandPNGBDBM50559919(CHEMBL4782725)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of EGFR (unknown origin) expressed in baculovirus system using fluorescein labeled PDGFR-tide substrate peptide preincubated for 60 mins f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Acerta Pharma

Curated by ChEMBL
LigandPNGBDBM50559919(CHEMBL4782725)
Affinity DataIC50: 0.540nMAssay Description:Inhibition of human recombinant full length N-terminal His6-tagged BTK expressed in baculovirus infected Sf9 cells using fluorescein labeled Blk/Lynt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Acerta Pharma

Curated by ChEMBL
LigandPNGBDBM50559919(CHEMBL4782725)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant human GST-tagged EGFR (668 to 1210 residues) expressed in baculovirus expression system using Tyr 04 peptide as substrate p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Acerta Pharma

Curated by ChEMBL
LigandPNGBDBM50559919(CHEMBL4782725)
Affinity DataIC50: 8.30nMAssay Description:Inhibition of His-tagged recombinant human His-tagged full length BTK expressed in baculovirus expression system using Tyr01 peptide as substrate pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase Tec(Human)
Acerta Pharma

Curated by ChEMBL
LigandPNGBDBM50559919(CHEMBL4782725)
Affinity DataIC50: 219nMAssay Description:Inhibition of His-tagged recombinant human TEC expressed in baculovirus expression system preincubated for 1 hr by Z'lyte assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetCytoplasmic tyrosine-protein kinase BMX(Human)
Acerta Pharma

Curated by ChEMBL
LigandPNGBDBM50559919(CHEMBL4782725)
Affinity DataIC50: 89nMAssay Description:Inhibition of His-tagged recombinant full length human His-tagged BMX cytoplasmic domain expressed in baculovirus expression system using tyrosine-1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Acerta Pharma

Curated by ChEMBL
LigandPNGBDBM50559919(CHEMBL4782725)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant full length human GST-tagged ITK expressed in baculovirus expression system using tyrosine-1 peptide as substrate preincuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase TXK(Human)
Acerta Pharma

Curated by ChEMBL
LigandPNGBDBM50559919(CHEMBL4782725)
Affinity DataIC50: 229nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged TXK (260 to 527 residues) expressed in baculovirus expression system using tyrosine-6 peptide a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Acerta Pharma

Curated by ChEMBL
LigandPNGBDBM50559919(CHEMBL4782725)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of His-tagged human recombinant ERBB2 (676 to 1255 residues) expressed in baculovirus expression system using Tyr 06 as substrate preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-4(Human)
Acerta Pharma

Curated by ChEMBL
LigandPNGBDBM50559919(CHEMBL4782725)
Affinity DataIC50: 37nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged ERBB4 catalytic domain (708 to 993 residues) expressed in baculovirus expression system using t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Acerta Pharma

Curated by ChEMBL
LigandPNGBDBM50559919(CHEMBL4782725)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant human GST-tagged JAK3 catalytic domain (781 to 1124 residues) expressed in baculovirus expression system using tyrosine-6 p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Acerta Pharma

Curated by ChEMBL
LigandPNGBDBM50559919(CHEMBL4782725)
Affinity DataEC50: >1.00E+3nMAssay Description:Inhibition of EGFR phosphorylation in human A431 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase Blk(Human)
Acerta Pharma

Curated by ChEMBL
LigandPNGBDBM50559919(CHEMBL4782725)
Affinity DataIC50: 72nMAssay Description:Inhibition of recombinant full length human His-tagged BLK cytoplasmic domain expressed in baculovirus expression system using tyrosine-1 peptide as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed