BDBM50559267 CHEMBL4778749

SMILES CC(C)n1cc(cn1)-c1nc(Nc2ccc3CN(CCO)CCc3c2)ncc1F

InChI Key InChIKey=LAQFGRIIXMUNAH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50559267   

TargetTyrosine-protein kinase JAK2(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50559267(CHEMBL4778749)
Affinity DataIC50: 651nMAssay Description:Inhibition of JAK2 V617F mutant in human SET-2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Mouse)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50559267(CHEMBL4778749)
Affinity DataIC50: 760nMAssay Description:Inhibition of JAK2 V617F mutant in mouse BaF3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50559267(CHEMBL4778749)
Affinity DataIC50: 547nMAssay Description:Inhibition of FLT3 ITD mutant in human MOLM13 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed