BDBM50558815 CHEMBL4742035

SMILES CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](CS)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CS)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CS)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)CNC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CS)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CS)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](N)CCCCN)C(C)C)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CO)C(N)=O

InChI Key InChIKey=ILQNQNXHECHYOX-UHFFFAOYSA-N

Data  6 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50558815   

TargetSodium channel protein type 8 subunit alpha(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50558815(CHEMBL4742035)
Affinity DataEC50:  72nMAssay Description:Inhibition of human Nav1.6 expressed in HEK293 cells incubated for 30 mins by FLIPRTetra fluorescent membrane potential assayMore data for this Ligand-Target Pair
Ligand InfoKEGGSimilars
In DepthDetails Article
PubMed
TargetSodium channel protein type 8 subunit alpha(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50558815(CHEMBL4742035)
Affinity DataEC50:  72.4nMAssay Description:Inhibition of human Nav1.6 expressed in HEK293 cells incubated for 30 mins by FLIPRTetra fluorescent membrane potential assayMore data for this Ligand-Target Pair
Ligand InfoKEGGSimilars
In DepthDetails Article
PubMed
TargetSodium channel protein type 8 subunit alpha(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50558815(CHEMBL4742035)
Affinity DataEC50:  72nMAssay Description:Inhibition of human Nav1.6 expressed in HEK293 cells incubated for 30 mins by FLIPRTetra fluorescent membrane potential assayMore data for this Ligand-Target Pair
Ligand InfoKEGGSimilars
In DepthDetails Article
PubMed
TargetSodium channel protein type 8 subunit alpha(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50558815(CHEMBL4742035)
Affinity DataEC50:  72.4nMAssay Description:Inhibition of human Nav1.6 expressed in HEK293 cells incubated for 30 mins by FLIPRTetra fluorescent membrane potential assayMore data for this Ligand-Target Pair
Ligand InfoKEGGSimilars
In DepthDetails Article
PubMed
TargetSodium channel protein type 8 subunit alpha(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50558815(CHEMBL4742035)
Affinity DataEC50:  6.20nMAssay Description:Inhibition of human Nav1.6 expressed in HEK293 cells assessed as decrease in peak current at pulses to 0 mV by whole cell patch clamp assayMore data for this Ligand-Target Pair
Ligand InfoKEGGSimilars
In DepthDetails Article
PubMed
TargetSodium channel protein type 8 subunit alpha(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50558815(CHEMBL4742035)
Affinity DataEC50:  6.30nMAssay Description:Inhibition of human Nav1.6 expressed in HEK293 cells assessed as decrease in peak current at pulses to 0 mV by whole cell patch clamp assayMore data for this Ligand-Target Pair
Ligand InfoKEGGSimilars
In DepthDetails Article
PubMed