BDBM50557564 CHEMBL4783397
SMILES Nc1nc2sc(CCCCc3cc(cs3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)cc2c(=O)[nH]1
InChI Key InChIKey=UEVAKXKCGSGJIG-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 50557564
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human RFC expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTiter-bl...More data for this Ligand-Target Pair
Affinity DataIC50: 0.910nMAssay Description:Inhibition of human FRalpha expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTite...More data for this Ligand-Target Pair
Affinity DataIC50: 1.20nMAssay Description:Inhibition of human FRbeta expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTiter...More data for this Ligand-Target Pair
TargetProton-coupled folate transporter(Human)
Wayne State University School of Medicine
Curated by ChEMBL
Wayne State University School of Medicine
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human PCFT expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTiter-b...More data for this Ligand-Target Pair
TargetBifunctional purine biosynthesis protein ATIC(Human)
Wayne State University School of Medicine
Curated by ChEMBL
Wayne State University School of Medicine
Curated by ChEMBL
Affinity DataKi: 1.07E+3nMAssay Description:Inhibition of human full length N-terminal His-tagged ATIC expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in THF formatio...More data for this Ligand-Target Pair