BDBM50557563 CHEMBL4746688

SMILES CN(C)C(=O)c1ccccc1Nc1nc(Nc2ccc3nc(CN4CCCC4)[nH]c3c2)ncc1Cl

InChI Key InChIKey=WTEVQSAOHYKUTI-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50557563   

TargetALK tyrosine kinase receptor(Human)
Cancer Hospital of China Medical University

Curated by ChEMBL
LigandPNGBDBM50557563(CHEMBL4746688)
Affinity DataIC50: 3.40nMAssay Description:Inhibition of human N-terminal GST-fused ALK cytoplasmic domain (1058 to 1620 residues) expressed in baculovirus infected Sf21 insect cells using Src...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Cancer Hospital of China Medical University

Curated by ChEMBL
LigandPNGBDBM50557563(CHEMBL4746688)
Affinity DataIC50: 5.30nMAssay Description:Inhibition of human N-terminal GST-fused ALK L1196M mutant cytoplasmic domain (1058 to 1620 residues) expressed in baculovirus infected Sf21 insect c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Cancer Hospital of China Medical University

Curated by ChEMBL
LigandPNGBDBM50557563(CHEMBL4746688)
Affinity DataIC50: 13nMAssay Description:Inhibition of human N-terminal GST-fused ALK G1202R mutant cytoplasmic domain (1058 to 1620 residues) expressed in baculovirus infected Sf21 insect c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Cancer Hospital of China Medical University

Curated by ChEMBL
LigandPNGBDBM50557563(CHEMBL4746688)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of N-terminal GST-tagged human EGFR cytoplasmic domain (669 to 1210 residues) expressed in baculovirus infected Sf21 insect cells using Sr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Cancer Hospital of China Medical University

Curated by ChEMBL
LigandPNGBDBM50557563(CHEMBL4746688)
Affinity DataIC50: 103nMAssay Description:Inhibition of N-terminal GST-tagged human FLT3 cytoplasmic domain (564 to 993 residues) expressed in baculovirus infected Sf21 insect cells using Src...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed