BDBM50557560 CHEMBL4760438

SMILES CN1CCN(Cc2nc3ccc(Nc4ncc(Cl)c(Nc5ccccc5NS(C)(=O)=O)n4)cc3[nH]2)CC1

InChI Key InChIKey=FCKKFYWNFKXOIH-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50557560   

TargetALK tyrosine kinase receptor(Human)
Cancer Hospital of China Medical University

Curated by ChEMBL
LigandPNGBDBM50557560(CHEMBL4760438)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of human N-terminal GST-fused ALK cytoplasmic domain (1058 to 1620 residues) expressed in baculovirus infected Sf21 insect cells using Src...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Cancer Hospital of China Medical University

Curated by ChEMBL
LigandPNGBDBM50557560(CHEMBL4760438)
Affinity DataIC50: 4.90nMAssay Description:Inhibition of human N-terminal GST-fused ALK L1196M mutant cytoplasmic domain (1058 to 1620 residues) expressed in baculovirus infected Sf21 insect c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Cancer Hospital of China Medical University

Curated by ChEMBL
LigandPNGBDBM50557560(CHEMBL4760438)
Affinity DataIC50: 7nMAssay Description:Inhibition of human N-terminal GST-fused ALK G1202R mutant cytoplasmic domain (1058 to 1620 residues) expressed in baculovirus infected Sf21 insect c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Cancer Hospital of China Medical University

Curated by ChEMBL
LigandPNGBDBM50557560(CHEMBL4760438)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of N-terminal GST-tagged human EGFR cytoplasmic domain (669 to 1210 residues) expressed in baculovirus infected Sf21 insect cells using Sr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Cancer Hospital of China Medical University

Curated by ChEMBL
LigandPNGBDBM50557560(CHEMBL4760438)
Affinity DataIC50: 135nMAssay Description:Inhibition of N-terminal GST-tagged human FLT3 cytoplasmic domain (564 to 993 residues) expressed in baculovirus infected Sf21 insect cells using Src...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed