BDBM50557558 CHEMBL4747513

SMILES CN(C)Cc1nc2ccc(Nc3ncc(Cl)c(Nc4ccccc4NS(C)(=O)=O)n3)cc2[nH]1

InChI Key InChIKey=OHMKUKNYYOHYNP-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50557558   

TargetALK tyrosine kinase receptor(Human)
Cancer Hospital of China Medical University

Curated by ChEMBL
LigandPNGBDBM50557558(CHEMBL4747513)
Affinity DataIC50: 4nMAssay Description:Inhibition of human N-terminal GST-fused ALK cytoplasmic domain (1058 to 1620 residues) expressed in baculovirus infected Sf21 insect cells using Src...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Cancer Hospital of China Medical University

Curated by ChEMBL
LigandPNGBDBM50557558(CHEMBL4747513)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of human N-terminal GST-fused ALK L1196M mutant cytoplasmic domain (1058 to 1620 residues) expressed in baculovirus infected Sf21 insect c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Cancer Hospital of China Medical University

Curated by ChEMBL
LigandPNGBDBM50557558(CHEMBL4747513)
Affinity DataIC50: 8.20nMAssay Description:Inhibition of human N-terminal GST-fused ALK G1202R mutant cytoplasmic domain (1058 to 1620 residues) expressed in baculovirus infected Sf21 insect c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Cancer Hospital of China Medical University

Curated by ChEMBL
LigandPNGBDBM50557558(CHEMBL4747513)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of N-terminal GST-tagged human EGFR cytoplasmic domain (669 to 1210 residues) expressed in baculovirus infected Sf21 insect cells using Sr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Cancer Hospital of China Medical University

Curated by ChEMBL
LigandPNGBDBM50557558(CHEMBL4747513)
Affinity DataIC50: 200nMAssay Description:Inhibition of N-terminal GST-tagged human FLT3 cytoplasmic domain (564 to 993 residues) expressed in baculovirus infected Sf21 insect cells using Src...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed