BDBM50556542 CHEMBL4780771

SMILES Cc1nc(OCc2ccc(F)cc2)c(cc1Br)C(=O)NC1CCCCCC1

InChI Key InChIKey=LEHIEWISZPIBHW-UHFFFAOYSA-N

Data  2 KI  4 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50556542   

TargetFatty-acid amide hydrolase 1(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50556542(CHEMBL4780771)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of FAAH in human U937 cells using [ethanolamine-1-3H]AEA as substrate preincubated for 15 mins followed by substrate addition and measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetMonoglyceride lipase(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50556542(CHEMBL4780771)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MAGL in human U937 cells using [glycerol-1,2,3-3H]2-OG as substrate preincubated for 15 mins followed by substrate addition and measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetMonoacylglycerol lipase ABHD6(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50556542(CHEMBL4780771)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human ABHD6 expressed in HEK293 cells using 2-OG as substrate preincubated for 30 mins followed by substrate addition and measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetLysophosphatidylserine lipase ABHD12(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50556542(CHEMBL4780771)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of human ABHD12 expressed in HEK293 cells using 2-OG as substrate preincubated for 30 mins followed by substrate addition and measured aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50556542(CHEMBL4780771)
Affinity DataEC50:  586nMAssay Description:Agonist activity at human CB1R expressed in CHO cell membranes after 90 mins by [35S]GTPgammaS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50556542(CHEMBL4780771)
Affinity DataEC50:  32nMAssay Description:Agonist activity at human CB2R expressed in CHO cell membranes after 90 mins by [35S]GTPgammaS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50556542(CHEMBL4780771)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H]CP55940 from recombinant human CB2R expressed in CHO cell membranes incubated for 90 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50556542(CHEMBL4780771)
Affinity DataKi:  76nMAssay Description:Displacement of [3H]CP55940 from recombinant human CB1R expressed in CHO cell membranes incubated for 90 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed