BDBM50554975 CHEMBL4595209

SMILES COCc1ccc(cc1)-c1ccc(cc1)N(C[C@@H](N)[C@@H](C)OC)C(=O)[C@@H]1C[C@H]1c1ccccn1

InChI Key InChIKey=XCHHIKJEGXHKLQ-UHFFFAOYSA-N

Data  1 KI  2 Kd  7 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50554975   

TargetProbable G-protein coupled receptor 88(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50554975(CHEMBL4595209)
Affinity DataEC50:  47nMAssay Description:Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetProbable G-protein coupled receptor 88(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50554975(CHEMBL4595209)
Affinity DataEC50:  47nMAssay Description:Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetProbable G-protein coupled receptor 88(Mouse)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50554975(CHEMBL4595209)
Affinity DataEC50:  25nMAssay Description:Agonist activity at GPR88 in mouse striatal membrane assessed as [35S]-GTPgammaS-binding by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetProbable G-protein coupled receptor 88(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50554975(CHEMBL4595209)
Affinity DataKd:  85nMAssay Description:Binding affinity to PPLS-HA tagged human GPR88 expressed in CHO cell membrane by filtration methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetProbable G-protein coupled receptor 88(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50554975(CHEMBL4595209)
Affinity DataEC50:  45nMAssay Description:Agonist activity at GPR88 (unknown origin) transfected in HEK293 cells assessed as cAMP level by GloSensor cAMP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetProbable G-protein coupled receptor 88(Mouse)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50554975(CHEMBL4595209)
Affinity DataKd:  41nMAssay Description:Binding affinity to GPR88 in mouse striatal membrane by filtration methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetProbable G-protein coupled receptor 88(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50554975(CHEMBL4595209)
Affinity DataEC50:  45nMAssay Description:Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetProbable G-protein coupled receptor 88(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50554975(CHEMBL4595209)
Affinity DataEC50:  45nMAssay Description:Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetProbable G-protein coupled receptor 88(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50554975(CHEMBL4595209)
Affinity DataEC50:  65nMAssay Description:Displacement of [35S]GTPgammaS from PPLS-HA tagged human GPR88 overexpressed in CHO cells membrane incubated for 60 mins radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetProbable G-protein coupled receptor 88(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50554975(CHEMBL4595209)
Affinity DataKi:  224nMAssay Description:Displacement of [3H]RTI-33 from GPR88 (unknown origin) by competition binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed