BDBM50553488 CHEMBL4743691

SMILES COc1cc(F)ccc1-c1ncnc(Nc2cccc(CS(N)(=O)=O)c2)n1

InChI Key InChIKey=MGCPJSMHKDVTGW-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50553488   

TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Endotherm

Curated by ChEMBL
LigandPNGBDBM50553488(CHEMBL4743691)
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant full length His-tagged human CDK9/cyclin T1 expressed in baculovirus expression system using biotinylated peptide biotin-Tt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
LigandPNGBDBM50553488(CHEMBL4743691)
Affinity DataIC50: 1.08E+3nMAssay Description:Inhibition of recombinant GST-tagged human CDK2/GST-tagged cyclin E expressed in sf9 cells using biotinylated peptide biotin-Ttds-YISPLKSPYKISEG as s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Endotherm

Curated by ChEMBL
LigandPNGBDBM50553488(CHEMBL4743691)
Affinity DataIC50: 11nMAssay Description:Inhibition of His-tagged human CDK9/cyclin T1 expressed in insect cells using biotin Ttds-YISPLKSPYKISEG as substrate preincubated for 15 mins follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
LigandPNGBDBM50553488(CHEMBL4743691)
Affinity DataIC50: 1.08E+3nMAssay Description:Inhibition of His-tagged human CDK2/cyclin E1 expressed in insect cells using biotin Ttds-YISPLKSPYKISEG as substrate preincubated for 15 mins follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Nankai University

Curated by ChEMBL
LigandPNGBDBM50553488(CHEMBL4743691)
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant human full length CDK9/cyclin T1 expressed in sf9 cells preincubated for 15 mins followed by substrate addition and measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Nankai University

Curated by ChEMBL
LigandPNGBDBM50553488(CHEMBL4743691)
Affinity DataIC50: 1.08E+3nMAssay Description:Inhibition of recombinant human CDK2/cyclin E expressed in sf9 cells preincubated for 15 mins followed by substrate addition and measured after 25 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed