BDBM50552702 CHEMBL4748154

SMILES CC1(C)OC(=O)c2ccc(Nc3ncc(-c4nnco4)c(N[C@H](CO)c4ccccc4)n3)cc12

InChI Key InChIKey=RVSSNRBUPQUIEG-UHFFFAOYSA-N

Data  17 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50552702   

TargetMitogen-activated protein kinase kinase kinase kinase 4(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50552702(CHEMBL4748154)
Affinity DataIC50: 276nMAssay Description:Inhibition of N-terminal GST-tagged human recombinant HGK (1 to 328 residues) expressed in bacuovirus-infected Sf9 cells using myelin basic protein a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50552702(CHEMBL4748154)
Affinity DataIC50: 300nMAssay Description:Inhibition of HPK1 in human PBMC cells assessed as inhibition of SLP76 phosphorylation incubated for 4 hr by HTRF analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50552702(CHEMBL4748154)
Affinity DataIC50: 2.09E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50552702(CHEMBL4748154)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate incubated for 10 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 3(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50552702(CHEMBL4748154)
Affinity DataIC50: 143nMAssay Description:Inhibition of GLK (unknown origin) using MBP protein as substrate in presence of ATP preincubated for 15 mins followed by substrate addition and meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50552702(CHEMBL4748154)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of HPK1 (unknown origin) using MBP protein as substrate in presence of ATP preincubated for 15 mins followed by substrate addition and mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50552702(CHEMBL4748154)
Affinity DataIC50: 290nMAssay Description:Inhibition of HPK1 (unknown origin) assessed as inhibition of SLP-76 phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50552702(CHEMBL4748154)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of HPK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 5(Homo sapiens)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50552702(CHEMBL4748154)
Affinity DataIC50: 232nMAssay Description:Inhibition of N-terminal GST-tagged human full length recombinant KHS expressed in baculovirus-infected Sf9 cells using myelin basic protein as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50552702(CHEMBL4748154)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged HPK1 (1 to 346 residues) expressed in baculovirus infected Sf9 cells using NH2-fluorescein-RFAR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 3(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50552702(CHEMBL4748154)
Affinity DataIC50: 42nMAssay Description:Inhibition of N-terminal GST-tagged human recombinant GLK (1 to 380 residues) expressed in baculovirus-infected Sf9 cells using PKA substrate by ADP-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 2(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50552702(CHEMBL4748154)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminal GST-tagged human full length recombinant GCK expressed in baculovirus-infected Sf9 cells using myelin basic protein as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50552702(CHEMBL4748154)
Affinity DataIC50: 5.5nMAssay Description:Inhibition of N-terminal GST-tagged human recombinant HPK1 (1 to 346 residues) expressed in baculovirus-infected Sf9 cells using myelin basic protein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50552702(CHEMBL4748154)
Affinity DataIC50: 15nMAssay Description:Inhibition of HPK1 (unknown origin) using myelin basic protein as substrate incubated for 60 mins in presence of ATP by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50552702(CHEMBL4748154)
Affinity DataIC50: 290nMAssay Description:Inhibition of HPK1 in anti-CD3/anti-CD28-stimulated human T-cells assessed as inhibition of SLP76 phosphorylation preincubated for 1 hr followed by a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 3(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50552702(CHEMBL4748154)
Affinity DataIC50: 140nMAssay Description:Inhibition of GLK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50552702(CHEMBL4748154)
Affinity DataIC50: 59nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed