BDBM50552098 CHEMBL4792487::US20230399314, Reference compound 3

SMILES CC(C)[C@H]1C[C@@H]1c1cc(nnc1C)-c1c[nH]c(=O)[nH]c1=O

InChI Key InChIKey=WHRUIISQCORGKK-UHFFFAOYSA-N

Data  11 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50552098   

Target5'-nucleotidase(Human)
Arcus Biosciences

Curated by ChEMBL
LigandPNGBDBM50552098(CHEMBL4792487 | US20230399314, Reference compound ...)
Affinity DataEC50:  213nMAssay Description:Inhibition of CD73 in human serum using 13C5-15N5-AMP as substrate preincubated for 60 mins followed by substrate addition and measured after 15 mins...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5'-nucleotidase(Human)
Arcus Biosciences

Curated by ChEMBL
LigandPNGBDBM50552098(CHEMBL4792487 | US20230399314, Reference compound ...)
Affinity DataIC50: 7.30nMAssay Description:Inhibition of CD73 in human Calu-6 cells using AMP as substrate incubated for 60 mins by RF-MS/MSMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5'-nucleotidase(Human)
Arcus Biosciences

Curated by ChEMBL
LigandPNGBDBM50552098(CHEMBL4792487 | US20230399314, Reference compound ...)
Affinity DataIC50: 28nMAssay Description:Inhibition of human C-terminal 6His-tagged CD73 (1 to 547 residues) expressed in HEK293F cells using 2 uM AMP as substrate by rapidfire mass spectrom...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5'-nucleotidase(Human)
Arcus Biosciences

Curated by ChEMBL
LigandPNGBDBM50552098(CHEMBL4792487 | US20230399314, Reference compound ...)
Affinity DataIC50: 8.30nMAssay Description:Inhibition of human C-terminal 6His-tagged CD73 (1 to 547 residues) expressed in HEK293F cells using 50 uM AMP as substrate by rapidfire mass spectro...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5'-nucleotidase(Human)
Arcus Biosciences

Curated by ChEMBL
LigandPNGBDBM50552098(CHEMBL4792487 | US20230399314, Reference compound ...)
Affinity DataIC50: 6.60nMAssay Description:Inhibition of human C-terminal 6His-tagged CD73 (1 to 547 residues) expressed in HEK293F cells using 16.7 uM AMP as substrate by rapidfire mass spect...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5'-nucleotidase(Human)
Arcus Biosciences

Curated by ChEMBL
LigandPNGBDBM50552098(CHEMBL4792487 | US20230399314, Reference compound ...)
Affinity DataIC50: 8.80nMAssay Description:Inhibition of human C-terminal 6His-tagged CD73 (1 to 547 residues) expressed in HEK293F cells using 5.6 uM AMP as substrate by rapidfire mass spectr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5'-nucleotidase(Human)
Arcus Biosciences

Curated by ChEMBL
LigandPNGBDBM50552098(CHEMBL4792487 | US20230399314, Reference compound ...)
Affinity DataIC50: 20nMAssay Description:Inhibition of human C-terminal 6His-tagged CD73 (1 to 547 residues) expressed in HEK293F cells using 1.9 uM AMP as substrate by rapidfire mass spectr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5'-nucleotidase(Human)
Arcus Biosciences

Curated by ChEMBL
LigandPNGBDBM50552098(CHEMBL4792487 | US20230399314, Reference compound ...)
Affinity DataIC50: 63nMAssay Description:Inhibition of human C-terminal 6His-tagged CD73 (1 to 547 residues) expressed in HEK293F cells using 0.61 uM AMP as substrate by rapidfire mass spect...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5'-nucleotidase(Human)
Arcus Biosciences

Curated by ChEMBL
LigandPNGBDBM50552098(CHEMBL4792487 | US20230399314, Reference compound ...)
Affinity DataIC50: 151nMAssay Description:Inhibition of human C-terminal 6His-tagged CD73 (1 to 547 residues) expressed in HEK293F cells using 0.21 uM AMP as substrate by rapidfire mass spect...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5'-nucleotidase(Human)
Arcus Biosciences

Curated by ChEMBL
LigandPNGBDBM50552098(CHEMBL4792487 | US20230399314, Reference compound ...)
Affinity DataIC50: 290nMAssay Description:Inhibition of human C-terminal 6His-tagged CD73 (1 to 547 residues) expressed in HEK293F cells using 0.069 uM AMP as substrate by rapidfire mass spec...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5'-nucleotidase(Human)
Arcus Biosciences

Curated by ChEMBL
LigandPNGBDBM50552098(CHEMBL4792487 | US20230399314, Reference compound ...)
Affinity DataIC50: 409nMAssay Description:Inhibition of human CD73 (1 to 547 residues) expressed in HEK293F cells using 0.023 uM AMP as substrate by rapidfire mass spectrometry assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5'-nucleotidase(Human)
Arcus Biosciences

Curated by ChEMBL
LigandPNGBDBM50552098(CHEMBL4792487 | US20230399314, Reference compound ...)
Affinity DataIC50: 27nMAssay Description:The test was performed using Tris-MgCl2 buffer containing 25 mM Tris (Biosharp; 77-86-1) and 25 mM MgCl2 (Nanjing Chemical Reagent Co., Ltd.; 7791-18...More data for this Ligand-Target Pair
In DepthDetails
US Patent