BDBM50550520 CHEMBL4789744

SMILES Clc1ccc(CCN2CCN(CC2)c2ccccc2-c2cc(cc(c2)C(=O)NCCCN2CCCC2)C#N)cc1Cl

InChI Key InChIKey=UOFQGOWSZWZKPR-UHFFFAOYSA-N

Data  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50550520   

TargetN-lysine methyltransferase SMYD2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50550520(CHEMBL4789744)
Affinity DataIC50: 138nMAssay Description:Inhibition of SMYD2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetN-lysine methyltransferase SMYD2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50550520(CHEMBL4789744)
Affinity DataEC50:  425nMAssay Description:Inhibition of SMYD2 (unknown origin) expressed in in human U2OS cells assessed as reduction in monomethylated p53 levels incubated for 24 hrs by immu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetN-lysine methyltransferase SMYD2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50550520(CHEMBL4789744)
Affinity DataIC50: 670nMAssay Description:Inhibition of SMYD2 (unknown origin) expressed in in human U2OS cells assessed as reduction in monomethylated p53 levels incubated for 24 hrs by immu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetN-lysine methyltransferase SMYD2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50550520(CHEMBL4789744)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of SMYD2 (unknown origin) expressed in in human U2OS cells assessed as reduction in cell count incubated for 24 hrs by DAPI staining based...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed