BDBM50550131 CHEMBL4754904

SMILES Clc1ccnc(NC(=O)Cc2ccc3ccccc3c2)c1

InChI Key InChIKey=UPVVKGJGCKBECE-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50550131   

TargetSerine/threonine-protein kinase RIO2(Human)
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50550131(CHEMBL4754904)
Affinity DataIC50: 5.00E+3nMAssay Description:Displacement of tracer K5 from N-terminal nanoluciferase-tagged RIOK2 (unknown origin) expressed in HEK293 cells measured after 2 hrs by NanoBRET ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50550131(CHEMBL4754904)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of full length recombinant human MAPK8 using ATF2 as substrate incubated for 40 mins in presence of [gamma33P]ATP by radiometric scintilla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10(Human)
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50550131(CHEMBL4754904)
Affinity DataIC50: 520nMAssay Description:Inhibition of full length recombinant human MAPK10 using peptide substrate incubated for 40 mins in presence of [gamma33P]ATP by radiometric scintill...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 alpha(Human)
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50550131(CHEMBL4754904)
Affinity DataIC50: 860nMAssay Description:Inhibition of recombinant human GSK3alpha S449A mutant (2 to end residues) using YRRAAVPPSPSLSR peptide as substrate incubated for 40 mins in presenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetSNF-related serine/threonine-protein kinase(Human)
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50550131(CHEMBL4754904)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human SNRK E97G/P116A mutant (1 to 505 residues) using KKLRRTLSFAEPG peptide as substrate incubated for 40 mins in presence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 1(Human)
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50550131(CHEMBL4754904)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human HIPK1 (158 to 555 residues) using myelin ba as substrate incubated for 40 mins in presence of [gamma33P]ATP by radiometric scinti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed