BDBM50550127 CHEMBL4781866

SMILES Cc1ccnc(NC(=O)Cc2ccc3ccccc3c2)c1

InChI Key InChIKey=HPQZTEVMVAVGJO-UHFFFAOYSA-N

Data  7 IC50  8 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50550127   

TargetSerine/threonine-protein kinase RIO2(Human)
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50550127(CHEMBL4781866)
Affinity DataIC50: 1.46E+4nMAssay Description:Displacement of tracer K5 from N-terminal nanoluciferase-tagged RIOK2 (unknown origin) expressed in HEK293 cells measured after 2 hrs by NanoBRET ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50550127(CHEMBL4781866)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of full length recombinant human MAPK8 using ATF2 as substrate incubated for 40 mins in presence of [gamma33P]ATP by radiometric scintilla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10(Human)
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50550127(CHEMBL4781866)
Affinity DataIC50: 4.70E+3nMAssay Description:Inhibition of full length recombinant human MAPK10 using peptide substrate incubated for 40 mins in presence of [gamma33P]ATP by radiometric scintill...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 alpha(Human)
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50550127(CHEMBL4781866)
Affinity DataIC50: 5.20E+3nMAssay Description:Inhibition of recombinant human GSK3alpha S449A mutant (2 to end residues) using YRRAAVPPSPSLSR peptide as substrate incubated for 40 mins in presenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetSNF-related serine/threonine-protein kinase(Human)
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50550127(CHEMBL4781866)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human SNRK E97G/P116A mutant (1 to 505 residues) using KKLRRTLSFAEPG peptide as substrate incubated for 40 mins in presence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 1(Human)
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50550127(CHEMBL4781866)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human HIPK1 (158 to 555 residues) using myelin ba as substrate incubated for 40 mins in presence of [gamma33P]ATP by radiometric scinti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase RIO2(Human)
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50550127(CHEMBL4781866)
Affinity DataKd:  140nMAssay Description:Binding affinity to RIOK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50550127(CHEMBL4781866)
Affinity DataKd:  220nMAssay Description:Binding affinity to full length recombinant human MAPK8 using ATF2 as substrate incubated for 40 mins in presence of [gamma33P]ATP by radiometric sci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10(Human)
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50550127(CHEMBL4781866)
Affinity DataKd:  340nMAssay Description:Binding affinity to full length recombinant human MAPK10 using peptide substrate incubated for 40 mins in presence of [gamma33P]ATP by radiometric sc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 alpha(Human)
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50550127(CHEMBL4781866)
Affinity DataKd:  870nMAssay Description:Binding affinity to recombinant human GSK3alpha S449A mutant (2 to end residues) using YRRAAVPPSPSLSR peptide as substrate incubated for 40 mins in p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetSNF-related serine/threonine-protein kinase(Human)
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50550127(CHEMBL4781866)
Affinity DataKd:  890nMAssay Description:Binding affinity to recombinant human SNRK E97G/P116A mutant (1 to 505 residues) using KKLRRTLSFAEPG peptide as substrate incubated for 40 mins in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 1(Human)
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50550127(CHEMBL4781866)
Affinity DataKd:  1.10E+3nMAssay Description:Binding affinity to human HIPK1 (158 to 555 residues) using myelin ba as substrate incubated for 40 mins in presence of [gamma33P]ATP by radiometric ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase RIO2(Human)
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50550127(CHEMBL4781866)
Affinity DataIC50: 1.46E+4nMAssay Description:Displacement of fluorescent tracer K5 from N-terminal full-length NanoLuc-fused RIOK2 (unknown origin) expressed in HEK293 cells using NanoGlo substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase RIO2(Human)
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50550127(CHEMBL4781866)
Affinity DataKd:  150nMAssay Description:Binding affinity to wild-type human partial length RIOK2 (M1 to D313 residues) expressed in mammalian expression system assessed as dissociation cons...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase RIO2(Human)
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50550127(CHEMBL4781866)
Affinity DataKd:  160nMAssay Description:Binding affinity to RIOK2 (unknown origin) assessed as dissociation constant by KdELECT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed