BDBM50550093 CHEMBL4755950

SMILES C1CN=C(N1)c1cc2cc(ccc2o1)-c1cc2ccc(cc2[nH]1)C1=NCCN1

InChI Key InChIKey=YGJRBLKDKDPKDV-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50550093   

TargetProtein arginine N-methyltransferase 1(Human)
University of Georgia

Curated by ChEMBL
LigandPNGBDBM50550093(CHEMBL4755950)
Affinity DataIC50: 1.87E+4nMAssay Description:Inhibition of recombinant human His-tagged PRMT1 expressed in Escherichia coli BL21 (DE3) using biotin-labeled histone H4-20 as substrate incubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 3(Human)
University of Georgia

Curated by ChEMBL
LigandPNGBDBM50550093(CHEMBL4755950)
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibition of recombinant human His-tagged PRMT3 expressed in Escherichia coli BL21 (DE3) using biotin-labeled SMD1 as substrate incubated for 10 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetHistone-arginine methyltransferase CARM1(Human)
University of Georgia

Curated by ChEMBL
LigandPNGBDBM50550093(CHEMBL4755950)
Affinity DataIC50: 1.55E+5nMAssay Description:Inhibition of recombinant GST-tagged CARM1 (unknown origin) expressed in Escherichia coli using histone H3.3 peptide as substrate incubated for 120 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
University of Georgia

Curated by ChEMBL
LigandPNGBDBM50550093(CHEMBL4755950)
Affinity DataIC50: 5.00E+5nMAssay Description:Inhibition of PRMT5/MEP50 (unknown origin) using biotin-labeled histone H4-20 peptide as substrate incubated for 8 mins in presence of [3H]-SAM cofac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 6(Human)
University of Georgia

Curated by ChEMBL
LigandPNGBDBM50550093(CHEMBL4755950)
Affinity DataIC50: 1.29E+4nMAssay Description:Inhibition of PRMT6 (unknown origin) using biotin-labeled SMD1 as substrate incubated for 30 mins in presence of [3H]-SAM cofactor by scintillation p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 7(Human)
University of Georgia

Curated by ChEMBL
LigandPNGBDBM50550093(CHEMBL4755950)
Affinity DataIC50: 2.48E+5nMAssay Description:Inhibition of recombinant GST-tagged PRMT7 (unknown origin) expressed in Escherichia coli using biotin-labeled SMD1 as substrate incubated for 120 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 8(Human)
University of Georgia

Curated by ChEMBL
LigandPNGBDBM50550093(CHEMBL4755950)
Affinity DataIC50: 6.01E+4nMAssay Description:Inhibition of recombinant His-tagged human PRMT8 expressed in Escherichia coli BL21 (DE3) using biotin-labeled histone H4-20 peptide as substrate inc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Human)
University of Georgia

Curated by ChEMBL
LigandPNGBDBM50550093(CHEMBL4755950)
Affinity DataIC50: 3.97E+4nMAssay Description:Inhibition of recombinant His-tagged human G9a expressed in Escherichia coli BL21 (DE3) using biotin-labeled histone H3-20 peptide as substrate incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed