BDBM50550026 CHEMBL4786690

SMILES [H][C@]1(CC[C@@H](CC1)c1ccnc2ccc(F)cc12)[C@@H](C)NC(=O)c1ccc(Cl)cc1

InChI Key InChIKey=AOJCHFNHRLPISK-UHFFFAOYSA-N

Data  15 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50550026   

TargetAcetylcholine receptor subunit alpha(Human)
Bristol Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50550026(CHEMBL4786690)
Affinity DataIC50: 1.23E+4nMAssay Description:Inhibition of alpha1 nAChR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
Bristol Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50550026(CHEMBL4786690)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of alpha7 nAChR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
Bristol Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50550026(CHEMBL4786690)
Affinity DataEC50: >5.00E+4nMAssay Description:Transactivation of PXR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Bristol Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50550026(CHEMBL4786690)
Affinity DataIC50: 3.37E+3nMAssay Description:Inhibition of human CYP2C19More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetCytochrome P450 4B1(Human)
Bristol Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50550026(CHEMBL4786690)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of human CYP450More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
Bristol Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50550026(CHEMBL4786690)
Affinity DataIC50: 1.39E+3nMAssay Description:Inhibition of human CYP2C8More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Bristol Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50550026(CHEMBL4786690)
Affinity DataIC50: 740nMAssay Description:Inhibition of human CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Bristol Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50550026(CHEMBL4786690)
Affinity DataIC50: 25nMAssay Description:Inhibition of IDO1 in IFNgamma/LPS-stimulated human whole blood preincubated for 4 hrs followed by IFNgamma/LPS stimulation and incubated for 18 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Mouse)
Bristol Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50550026(CHEMBL4786690)
Affinity DataIC50: 2nMAssay Description:Inhibition of IDO1 in IFNgamma-stimulated mouse M109 cells preincubated for 2 hrs followed by IFNgamma stimulation and measured after 18 hrs byMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Bristol Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50550026(CHEMBL4786690)
Affinity DataIC50: 2nMAssay Description:Inhibition of IDO1 in IFNgamma-stimulated human HeLa cells preincubated for 2 hrs followed by IFNgamma stimulation and measured after 18 hrs byMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Bristol Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50550026(CHEMBL4786690)
Affinity DataIC50: 2nMAssay Description:Inhibition of IDO1 in IFNgamma-stimulated human HeLa cells preincubated for 2 hrs followed by recombinant human IFNgamma stimulation and measured aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Mouse)
Bristol Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50550026(CHEMBL4786690)
Affinity DataIC50: 2nMAssay Description:Inhibition of IDO1 in IFNgamma-stimulated mouse M109 cells preincubated for 2 hrs followed by recombinant murine IFNgamma stimulation and measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Bristol Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50550026(CHEMBL4786690)
Affinity DataIC50: 740nMAssay Description:Inhibition of human CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
Bristol Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50550026(CHEMBL4786690)
Affinity DataIC50: 1.39E+3nMAssay Description:Inhibition of human CYP2C8More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Bristol Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50550026(CHEMBL4786690)
Affinity DataIC50: 3.37E+3nMAssay Description:Inhibition of human CYP2C19More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Bristol Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50550026(CHEMBL4786690)
Affinity DataIC50: 50nMAssay Description:Inhibition of IDO1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed