BDBM50549889 CHEMBL4763457

SMILES CCS(=O)(=O)C1CC2(CC(CNc3nc4cnc(nc4n([C@@H](C)C4CC4)c3=O)-c3c(C)ncnc3C3CC3)C2)C1

InChI Key InChIKey=IXSJJZKNIGODLJ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50549889   

TargetNuclear receptor ROR-gamma(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50549889(CHEMBL4763457)
Affinity DataIC50: 370nMAssay Description:Antagonist activity at GAL4 DBD-fused human RORgamma LBD expressed in pGL4.3 luc2P/GAL4UAS/hygro and pBIND transfected HEK293 cells assessed as inhib...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50549889(CHEMBL4763457)
Affinity DataIC50: 120nMAssay Description:Antagonist activity at RORgamma in human PBMC assessed as reduction in anti-CD3/IL-23 stimulated IL-17 level measured after 3 days by MSD assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed