BDBM50549831 CHEMBL4740213

SMILES COCCNC(=O)Nc1nc(C)c(s1)C#Cc1ccncc1

InChI Key InChIKey=VHFXJTDUJSSVJC-UHFFFAOYSA-N

Data  1 KI  1 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50549831   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Vertex Pharmaceuticals

Curated by ChEMBL

LigandBDBM50549831(CHEMBL4740213)Copy SMILESCopy InChI

Affinity DataIC50: 760nMAssay Description:Inhibition of PI3Kgamma in human THP-1 cells assessed as reduction in Akt phosphorylation at Ser473 residueMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails Article
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TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Vertex Pharmaceuticals

Curated by ChEMBL

LigandBDBM50549831(CHEMBL4740213)Copy SMILESCopy InChI

Affinity DataKi:  43nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using PIP2 as substrate measured after 15 mins in presence of [33P]-ATP by liquid scintillation counting met...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails Article
Copy BDB DOIPubMed
Copy reaction URL