BDBM50546226 CHEMBL4778434

SMILES CC[C@@H](C)C[C@@H](C)\C=C(/C)\C=C\C=C\C=C(/C)C(=O)c1c(O)c(cn(O)c1=O)-c1ccc(O)cc1

InChI Key InChIKey=HFLOCDQLXUNJMN-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50546226   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50546226(CHEMBL4778434)
Affinity DataIC50: 6.31E+3nMAssay Description:Inhibition of recombinant His-tag fused full length human SHP2 expressed in Escherichia coli BL21 USING pNPP as substrate incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50546226(CHEMBL4778434)
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of His-tagged human PTP1B PTP domain expressed in Escherichia coli BL21 using p-nitrophenyl phosphate as substrate preincubated for 30 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50546226(CHEMBL4778434)
Affinity DataIC50: 6.30E+3nMAssay Description:Inhibition of His-tagged human SHP2 PTP domain expressed in Escherichia coli BL21 using p-nitrophenyl phosphate as substrate preincubated for 30 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50546226(CHEMBL4778434)
Affinity DataIC50: 3.47E+4nMAssay Description:Inhibition of His-tagged human SHP1 PTP domain expressed in Escherichia coli BL21 using p-nitrophenyl phosphate as substrate preincubated for 30 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50546226(CHEMBL4778434)
Affinity DataIC50: 6.31E+3nMAssay Description:Inhibition of SHP2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed