BDBM50546183 CHEMBL4744705

SMILES Nc1ncc(-c2nc(nc(n2)N2CCOCC2)N2CCOCC2)c(n1)C(F)F

InChI Key InChIKey=VZVYLEDIUUZTCW-UHFFFAOYSA-N

Data  2 KI  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50546183   

TargetTarget of rapamycin complex 2 subunit MAPKAP1(Human)
University of Basel

Curated by ChEMBL
LigandPNGBDBM50546183(CHEMBL4744705)
Affinity DataIC50: 17nMAssay Description:Inhibition of mTORC2 in human A2058 cells assessed as reduction in PKB phosphorylation at S473 residue incubated for 1 hr by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
University of Basel

Curated by ChEMBL
LigandPNGBDBM50546183(CHEMBL4744705)
Affinity DataIC50: 61nMAssay Description:Inhibition of mTORC1 in human A2058 cells assessed as reduction in ribosomal protein S6 phosphorylation at Ser235/236 residues incubated for 1 hr by ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 1A2(Human)
University of Basel

Curated by ChEMBL
LigandPNGBDBM50546183(CHEMBL4744705)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP1A2 (unknown origin) by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C19(Human)
University of Basel

Curated by ChEMBL
LigandPNGBDBM50546183(CHEMBL4744705)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP2C19 (unknown origin) by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
University of Basel

Curated by ChEMBL
LigandPNGBDBM50546183(CHEMBL4744705)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP2D6 (unknown origin) by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 3A4(Human)
University of Basel

Curated by ChEMBL
LigandPNGBDBM50546183(CHEMBL4744705)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP3A4 (unknown origin) by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
University of Basel

Curated by ChEMBL
LigandPNGBDBM50546183(CHEMBL4744705)
Affinity DataIC50: 80nMAssay Description:Inhibition of mTORC1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTarget of rapamycin complex 2 subunit MAPKAP1(Human)
University of Basel

Curated by ChEMBL
LigandPNGBDBM50546183(CHEMBL4744705)
Affinity DataIC50: 34nMAssay Description:Inhibition of mTORC2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50546183(CHEMBL4744705)
Affinity DataKi:  2.20nMAssay Description:Displacement of alexa fluor 647-labeled kinase tracer 314 from recombinant N-terminal His6-tagged p110alpha (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
University of Basel

Curated by ChEMBL
LigandPNGBDBM50546183(CHEMBL4744705)
Affinity DataKi:  33nMAssay Description:Displacement of alexa fluor 647-labeled kinase tracer 314 from recombinant human N-terminal GST-fused mTOR (1360 to 2549 residues) expressed in bacul...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed